ارزیابی پتانسیل های سیتوتوکسیک مهارکننده جدید سیکلواکسیژناز -2 در برابر لنفوسیت های سرطانی ALL و سالم و اثر ضد سرطانی آن از طریق مسیر میتوکندری

عنوان انگليسی

Evaluation of Cytotoxic Potentials of Novel Cyclooxygenase-2 Inhibitor Against ALL Lymphocytes and Normal Lymphocytes and Its Anticancer Effect Through Mitochondrial Pathway

خلاصه انگلیسی

In the present study, we searched selective cytotoxicity and mitochondria mediated apoptosis of novel COX-2 inhibitor 2-(4-(Methylsulfonyl)phenyl)imidazo[1,2-a] pyridine-8-carboxylic acid on B-lymphocytes and their mitochondria isolated from normal subjects and ALL patients’ blood. Our results showed this compound can selectively induce cellular and mitochondrial toxicity on ALL B-lymphocytes and mitochondria without any toxic effects on normal B-lymphocytes and their mitochondria. Taken together, the results of this study suggest that cancerous mitochondria are a potential target for the ALL B-lymphocytes. Selective toxicity of COX-2 inhibitor in cancerous mitochondria could be an attractive therapeutic option for the effective clinical management of therapy-resistant ALL.

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