title

ارتباط بین موتاسیون G1896A ویروس هپاتیت B و HBeAg در بیماران مبتلا به هپاتیت B مزمن

زند, ساره ، کرمی, چیمن ، حسین زاده عدلی, احمد ، تبرائی, علیجان ، خدابخشی, بهناز ، مرادی, عبدالوهاب (1394) ارتباط بین موتاسیون G1896A ویروس هپاتیت B و HBeAg در بیماران مبتلا به هپاتیت B مزمن. Jundishapur Journal of Microbiology ــ 8 (2). شاپا 2008-3645

متن کامل

[img]
پیش نمایش
متنی - نسخه چاپ شده
181kB

آدرس اینترنتی رسمی : https://sites.kowsarpub.com/jjm/articles/18880.htm...


عنوان انگليسی

Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients

خلاصه انگلیسی

Background: Hepatitis B virus (HBV) infection is an important health concern worldwide, with critical outcomes. Hepatitis B e antigen (HBeAg) negative chronic hepatitis B is frequently caused by a mutation (G1896A) in the hepatitis B virus (HBV) precore (PC) reading frame, which creates a stop codon, causing premature termination of the HBe protein. Objectives: This study aimed to investigate the G1896A PC mutation and its effect on HBeAg detection in chronic HBV patients. Patients and Methods: In this study, 120 chronic HBV patients neither vaccinated or who had benefited from immunoglobulin therapy, were recruited. The HBV-DNA was extracted from plasma and polymerase chain reaction (PCR) was performed. Positive PCR products were subjected to automated sequencing. The HBV serological markers [hepatitis B s antigen (HBsAg), HBeAg] were tested. Results: One hundred out of 120 (83.3%) patients were HBeAg negative and 100% were HBsAg positive. The comparison of nucleotide sequences with the reference sequence (Accession number: AB033559) in HBeAg negative patients showed that there was a high rate of mutations in G1896A (93.18%). Conclusions: This study indicates that the rate of G1896A mutation at the PC region among HBeAg negative patients, in the Golestan province of Iran, was similar to the average rate encountered in other parts of Iran. The PC stop codon mutation was detected in 93.18% of HBeAg negative patients. Further studies with larger sample sizes are required to elucidate the exact role of these mutations in the clinical course of chronic HBV infection.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :ساره زند
نویسنده :چیمن کرمی
نویسنده مسئول :عبدالوهاب مرادی
ضریب تاثیر و نمایه مجلات:IF: 0.0655 Indexed in: ISI, Scopus, Embase
کلیدواژه ها (انگلیسی):Iran, Mutation, Hepatitis B , Chronic, Hepatitis B e Antigens
موضوعات :QW میکروب شناسی و ایمنی شناسی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی
کد شناسایی :13419
ارائه شده توسط : دکتر چیمن کرمی
ارائه شده در تاریخ :10 مهر 1399 13:25
آخرین تغییر :10 مهر 1399 13:25

فقط پرسنل کتابخانه صفحه کنترل اسناد

Document Downloads

More statistics for this item...