title

تأثیر میکروشیمیایی بر فراوانی و شدت درگیری اعضای بدن در بیماران اسکلرودرمی ایران

فتحی بیطرف, سپیده ، نظرنیا, محمدعلی ، کماالی سراوستانی, اسکندر ، خدامرادی, زهرا (1398) تأثیر میکروشیمیایی بر فراوانی و شدت درگیری اعضای بدن در بیماران اسکلرودرمی ایران. Rheumatology Research ــ 4 (1). ص.ص.17-22. شاپا 2476-5856

متن کامل

[img]
پیش نمایش
متنی - نسخه چاپ شده
2MB

آدرس اینترنتی رسمی : http://www.rheumres.org/article_85102.html


عنوان انگليسی

The Effect of Microchimerism on Frequency and Severity of Organ Involvement in Iranian Scleroderma Patients

خلاصه انگلیسی

Microchimerism is defined as the presence of non-self and circulating cells in a host. The current study aimed to assess the effect of microchimerism on scleroderma major organ involvements. This cross-sectional study was conducted on 56 scleroderma patients registered in a tertiary rheumatology center of Shiraz University of Medical Sciences. Information on the patients’ demographics and disease complications was gathered through a review of medical records. Skin score was applied to better assess skin thickening. High Resolution CT-scan as well as pulmonary function test (PFT) results were also used to investigate pulmonary involvement in patients. Y chromosome serum levels were measured using Phenol Chloroform Extraction protocol and following real-time PCR. Fifty-six scleroderma patients with a mean age of 46±10 years were recruited in this study (58.9% with diffuse scleroderma and 41.07% with limited scleroderma). Other than skin thickening, the most common clinical presentation among the patients was interestitial lung disease (67.8%). No significant difference was found between Y chromosome levels of patients with either lung, cardiac, renal, or gastrointestinal involvement and those who did not have these complications. Y chromosome serum levels based on the results of PFT were also shown to have no significant difference. Moreover, no association was demonstrated between serum Y chromosome and skin score. The serum level of chromosome Y has no impact on the severity and frequency of major organ involvement in Iranian scleroderma patients.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :سپیده فتحی بیطرف
نویسنده مسئول :محمدعلی نظرنیا
نویسنده :اسکندر کماالی سراوستانی
نویسنده :زهرا خدامرادی
ضریب تاثیر و نمایه مجلات:Indexed in: google Scholar, Magiran
کلیدواژه ها (انگلیسی):Autoimmune Disease, Systemic Sclerosis, Scleroderma, Interestitial Lung Disease, Microchimerism
موضوعات :QW میکروب شناسی و ایمنی شناسی
WF سیستم تنفسی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :13521
ارائه شده توسط : دکتر سپیده بیطرف
ارائه شده در تاریخ :27 مهر 1399 11:23
آخرین تغییر :27 مهر 1399 11:23

فقط پرسنل کتابخانه صفحه کنترل اسناد

Document Downloads

More statistics for this item...