فتحی بیطرف, سپیده ، نظرنیا, محمدعلی ، کماالی سراوستانی, اسکندر ، خدامرادی, زهرا (1398) تأثیر میکروشیمیایی بر فراوانی و شدت درگیری اعضای بدن در بیماران اسکلرودرمی ایران. Rheumatology Research ــ 4 (1). ص.ص.17-22. شاپا 2476-5856
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آدرس اینترنتی رسمی : http://www.rheumres.org/article_85102.html
عنوان انگليسی
The Effect of Microchimerism on Frequency and Severity of Organ Involvement in Iranian Scleroderma Patients
خلاصه انگلیسی
Microchimerism is defined as the presence of non-self and circulating cells in a host. The current study aimed to assess the effect of microchimerism on scleroderma major organ involvements. This cross-sectional study was conducted on 56 scleroderma patients registered in a tertiary rheumatology center of Shiraz University of Medical Sciences. Information on the patients’ demographics and disease complications was gathered through a review of medical records. Skin score was applied to better assess skin thickening. High Resolution CT-scan as well as pulmonary function test (PFT) results were also used to investigate pulmonary involvement in patients. Y chromosome serum levels were measured using Phenol Chloroform Extraction protocol and following real-time PCR. Fifty-six scleroderma patients with a mean age of 46±10 years were recruited in this study (58.9% with diffuse scleroderma and 41.07% with limited scleroderma). Other than skin thickening, the most common clinical presentation among the patients was interestitial lung disease (67.8%). No significant difference was found between Y chromosome levels of patients with either lung, cardiac, renal, or gastrointestinal involvement and those who did not have these complications. Y chromosome serum levels based on the results of PFT were also shown to have no significant difference. Moreover, no association was demonstrated between serum Y chromosome and skin score. The serum level of chromosome Y has no impact on the severity and frequency of major organ involvement in Iranian scleroderma patients.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | سپیده فتحی بیطرف |
نویسنده مسئول : | محمدعلی نظرنیا |
نویسنده : | اسکندر کماالی سراوستانی |
نویسنده : | زهرا خدامرادی |
ضریب تاثیر و نمایه مجلات: | Indexed in: google Scholar, Magiran |
کلیدواژه ها (انگلیسی): | Autoimmune Disease, Systemic Sclerosis, Scleroderma, Interestitial Lung Disease, Microchimerism |
موضوعات : | QW میکروب شناسی و ایمنی شناسی WF سیستم تنفسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه داخلی ، قلب ، عفونی |
کد شناسایی : | 13521 |
ارائه شده توسط : | دکتر سپیده بیطرف |
ارائه شده در تاریخ : | 27 مهر 1399 11:23 |
آخرین تغییر : | 27 مهر 1399 11:23 |
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