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رابطه بین acidosis و hypercapnia با Cor pulmonale در بیماران مبتلا به بیماری‌های مزمن ریوی

حسینی نیا, سعید ، علی عسگرزاده خیاوی, شفق ، زمانی, بیژن ، حبیب زاده, افشین ، خیرجو, سعید ، صادقیه اهری, سعید (1397) رابطه بین acidosis و hypercapnia با Cor pulmonale در بیماران مبتلا به بیماری‌های مزمن ریوی. journal of research in clinical medicine ــ 5 (4). ص.ص.128-133. شاپا 2717-0616

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آدرس اینترنتی رسمی : https://jrcm.tbzmed.ac.ir/Article/JARCM_19763_2017...


عنوان انگليسی

The relationship between acidosis and hypercapnia with Cor pulmonale in patients with chronic obstructive pulmonary disease

خلاصه انگلیسی

Introduction: Cor pulmonale or right ventricular (RV) enlargement is cardiovascular complication of the chronic obstructive pulmonary disease (COPD). Hypoxic pulmonary vasoconstriction, hypercapnia, acidosis and pulmonary vascular remodeling are suggested as possible mechanisms of cor pulmonale. In this study, we aimed to evaluate the correlation between acidosis and hypercapnia with corpulmonale in patients with COPD. Methods: In this cross-sectional analytical study, 100 patients (56 men and 44 women with mean age of 66.53 ± 10.63 years) with moderate to severe COPD exacerbation were included. Complete history taking and physical examination as well as atrial blood gas, pulmonary function test (PFT) and echocardiography were performed. Disease severity was defined according to global initiative for obstructive lung disease (GOLD), Modified Medical Research Council (mMRC) and COPD Assessment Test (CAT) criteria. Patients with cor pulmonale were defined and findings were compared between patients with and without cor pulmonale. Results: Forty-two patients had cor pulmonale. There was no significant difference in hypercapnia between groups. Cor pulmonale patients, compared to non-cor pulmonale, had significantly lower forced expiratory volume in the first second (FEV1) (P = 0.020), higher tricuspid regurgitation (TR) (P = 0.001) and pulmonary hypertension (P = 0.020). There was significantly negative correlation between RV thickness with FEV1/forced vital capacity (FCV) (r = -0.239, P = 0.010) and RV size with FEV1/FVC (r = -0.312, P = 0.002) and positive correlation with partial pressure of carbon dioxide (PaCO2) (r = 0.312, P = 0.002) and bicarbonate (HCO3) (r = 0.258, P = 0.009). Conclusion: Cor pulmonale in the course of COPD accompanies with adverse outcome. These patients have worse spirometry and left ventricle echocardiographic findings, but have no difference in arterial blood gas (ABG) findings. Keywords: Chronic Obstructive Pulmonary Disease, Cor Pulmonale, Echocardiography, Spirometry

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :سعید حسینی نیا
نویسنده مسئول :شفق علی عسگرزاده خیاوی
نویسنده :بیژن زمانی
نویسنده :افشین حبیب زاده
نویسنده :سعید خیرجو
نویسنده :سعید صادقیه اهری
ضریب تاثیر و نمایه مجلات:Indexed in: Google Scholar, ISC, SID, Magiran
کلیدواژه ها (فارسی):بیماری مزمن انسدادی, اکوکاردیوگرافی, اکوکاردیوگرافی, بیماری انسدادی ریه
کلیدواژه ها (انگلیسی):Chronic Obstructive Pulmonary Disease, Cor Pulmonale, Echocardiography, Spirometry
موضوعات :WF سیستم تنفسی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :13746
ارائه شده توسط : دکتر شفق علی عسگرزاده
ارائه شده در تاریخ :29 آذر 1399 08:26
آخرین تغییر :13 دی 1399 13:09

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