احدی, عادل ، کاتبی, لیلا ، بهلولی, شهاب ، شرقی, افشان (1399) ارتباط بین استرس اکسیداتیو و وضعیت آنتی اکسیدان سرم و ویتامین دی در کودکان آسمی. Malaysian Journal of Medicine and Health Sciences ــ 17 (1). ص.ص.17-22. شاپا 1675-8544
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آدرس اینترنتی رسمی : https://medic.upm.edu.my/upload/dokumen/2020123014...
عنوان انگليسی
Association Between Oxidative Stress, Serum Antioxidant Status and Vitamin D in Asthmatic Children
خلاصه انگلیسی
Introduction: The role of vitamin D in prevention of many diseases have been confirmed by many studies recently. The aim of this study was to determine the levels of oxidative and anti-oxidative markers after administration of vitamin D in asthmatic children. Methods: This randomized clinical trial study has been done on 60 asthmatic children who randomly divided into two groups. One group group received a single dose of vitamin D (5000 ng/ml) and another group received placebo with the same dose in the form of prescribed vitamin D. The levels of 25 (OH) D were measured at the baseline and also levels of vitamin D, glutathione peroxidase 1 (GPx1) and Total Oxidative Capacity (TOC) were measured 10 days after prescription single dose of vitamin D. Results: The amount of Vitamin D at baseline in two drug and placebo groups were similar but at the end of 10 days in the drug group with 54.8±20.92 significantly higher than placebo group with 30.73±12.98. The GPx1 levels at the end of 10 days in the drug group with 44.2±30.9 significantly more than placebo group with 29.5±12.9. Overall TOC amount at the end of 10 days in the drug group with 15.29±3.38 IU was similar to placebo group with 15.06±3.53 IU. The levels of vitamin D in rural children was significantly more than urban children. Conclusion: The results showed that, vitamin D could significantly increase the amount of GPx1, hence it can be used as an appropriate drug in the treatment of asthmatic children.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | عادل احدی |
نویسنده : | لیلا کاتبی |
نویسنده مسئول : | افشان شرقی |
ضریب تاثیر و نمایه مجلات: | Indexed in: Scopus |
کلیدواژه ها (انگلیسی): | Asthma, Children, Glutathione, Vitamin D |
موضوعات : | WS بیماریهای کودکان |
بخش های دانشگاهی : | دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی |
کد شناسایی : | 13903 |
ارائه شده توسط : | کاربر غیر معتبر |
ارائه شده در تاریخ : | 19 بهمن 1399 13:45 |
آخرین تغییر : | 19 بهمن 1399 13:45 |
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