ارتباط بین پلی مورفیسم ژن های گلوتاتیون S ترانسفراز و خطر ابتلا به سرطان سینه در یک نمونه از جمعیت ایرانی

هاشمی, محمد and اسکندری نسب, ابراهیم and فضایلی, علی اکبر and طاهری, محسن and رضایی, حمزه and مشهدی, محمد علی and اربابی, فرشید and کیخوایی, محمد علی and جهان تیغ, مهدی and بهاری, غلامرضا (1391) ارتباط بین پلی مورفیسم ژن های گلوتاتیون S ترانسفراز و خطر ابتلا به سرطان سینه در یک نمونه از جمعیت ایرانی. Biomarkers in Medicine ــ 6 (6). pp. 797-803. شاپا 1752-0363

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Official URL: https://doi.org/10.2217/bmm.12.61


Association between polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer risk in a sample Iranian population

English Abstract

Aim: Genetic and environmental factors are risk factors for breast cancer. Our aim was to investigate the associations between genetic polymorphism of GST genes (GSTM1, GSTT1 and GSTP1) and susceptibility to breast cancer in an Iranian population. Materials & methods: This case-control study was carried out on 134 patients with breast cancer and 152 healthy, cancer-free women. GSTP1 polymorphism was determined using tetra-primer amplification refractory mutation system PCR assay and GSTM1 and GSTT1 were genotyped by a multiplex PCR. Results: We found that the GSTM1 null genotype is a risk factor for predisposition to breast cancer (odds ratio [OR] = 2.01; 95% CI = 1.78-3.45; p = 0.010). No significant difference was found between the groups regarding GSTT1 null genotype (p > 0.05). The GSTP1 Ile/Val and Val/Val genotypes were associated with breast cancer risk (OR = 3.29; 95% CI = 1.84-5.91; p < 0.0001 and OR = 20.68; 95% CI = 5.66-75.60; p < 0.0001, respectively). Conclusion: In summary, GSTM1 and GSTP1, but not GSTT1 genetic polymorphisms are associated with increased risk of breast cancer in our population.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد هاشمی
نویسنده مسئول :ابراهیم اسکندری نسب
نویسنده :علی اکبر فضایلی
نویسنده :محسن طاهری
نویسنده :حمزه رضایی
نویسنده :محمد علی مشهدی
نویسنده :فرشید اربابی
نویسنده :محمد علی کیخوایی
نویسنده :مهدی جهان تیغ
نویسنده :غلامرضا بهاری
Additional Information:IF: 3.217 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):breast cancer, glutathione S-transferase, polymorphism
Subjects:QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:13931
Deposited By: Dr. Aliakbar Fazaeli
Deposited On:13 Nov 1399 11:12
Last Modified:13 Nov 1399 11:12

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