title

ارتباط پلی مورفیسم ژنی گلوتاتیون S-ترانسفراز با خطر ابتلا به کبد چرب غیر الکلی در زاهدان، جنوب ایران

هاشمی, محمد and اسکندری نسب, ابراهیم and فضایلی, علی اکبر and بهاری, علی and هاشمزهی, نورالله and شفیعی پور, سارا and طاهری, محسن and موذنی رودی, عبدالکریم and ذاکری, زهرا and بخشی پور, علیرضا and قوامی, سعید (1391) ارتباط پلی مورفیسم ژنی گلوتاتیون S-ترانسفراز با خطر ابتلا به کبد چرب غیر الکلی در زاهدان، جنوب ایران. DNA and Cell Biology ــ 31 (5). pp. 672-677. شاپا 1044-5498

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Official URL: https://www.liebertpub.com/doi/10.1089/dna.2011.13...


Title

Association of genetic polymorphisms of glutathione-S-transferase genes (GSTT1, GSTM1, and GSTP1) and susceptibility to nonalcoholic fatty liver disease in Zahedan, Southeast Iran

English Abstract

Oxidative damage is thought to play a pivotal role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Glutathione-S-transferases (GSTs) are involved in cell protection against oxidative stress. We examined whether GSTM1, GSTT1, and GSTP1 polymorphisms are associated with NAFLD in a sample of the Iranian population. The current case-control study included 83 patients with NAFLD and 93 healthy subjects. The GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction (PCR). The GSTP1 polymorphism was detected by tetra amplification refractory mutation system-PCR assay. The GSTM1-null genotype was significantly associated with the development of NAFLD (odds ratios [OR]=2.171, 95% confidence intervals [CI]=1.188-3.970, p=0.015). The GSTP1 Val allele was shown to be a risk factor for NAFLD (OR=1.739, 95% CI=1.089-2.777, p=0.024). The GSTT1 polymorphism was not significantly different between control and patient groups (p=0.221). This study showed that GSTM1 and GSTP1, but not GSTT1, genetic polymorphisms are associated with NAFLD in a sample of the Iranian population, and may be used to determine the risk of development of NAFLD.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :محمد هاشمی
نویسنده اول :ابراهیم اسکندری نسب
نویسنده :علی اکبر فضایلی
نویسنده :علی بهاری
نویسنده :نورالله هاشمزهی
نویسنده :سارا شفیعی پور
نویسنده :محسن طاهری
نویسنده :عبدالکریم موذنی رودی
نویسنده :زهرا ذاکری
نویسنده :علیرضا بخشی پور
نویسنده :سعید قوامی
Additional Information:IF: 2.344 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):NAFLD , Adult , Fatty Liver , NAFLD , polymorphism
Subjects:QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:13932
Deposited By: Dr. Aliakbar Fazaeli
Deposited On:13 Nov 1399 11:22
Last Modified:13 Nov 1399 11:22

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