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ارتباط متقابل ژنوتیپ Helicobacter pylori oipA با خطر زخم معده و سرطان معده

فعلی, ام البنین ، بختی, سیده زهرا ، لطیفی نوید, سعید ، ظاهری, صابر ، یزدانبد, عباس (1399) ارتباط متقابل ژنوتیپ Helicobacter pylori oipA با خطر زخم معده و سرطان معده. Infection, Genetics and Evolution ــ 10 (104720). ص.ص.1-5. شاپا 1567-1348

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عنوان انگليسی

Contrasting association of Helicobacter pylori oipA genotype with risk of peptic ulceration and gastric cancer

خلاصه انگلیسی

Helicobacter pylori OipA (outer inflammatory protein A) is an outer membrane protein that involves in the binding and colonization of the bacterium in the stomach. The oipA status is associated with the risk of peptic ulcerations (PUs) and gastric cancer (GC) diseases. However, the association trend with PUs compared to GC is often different and highly challenging. We therefore aimed to determine the presence of this genotype in Iranian strains and assess its association with the risk of PUs and GC in a larger number of samples. A total of 319 strains were obtained from 172 patients with non-atrophic gastritis (NAG), 52 with PUs and 95 with GC. The prevalence of the oipA+ vs. oipA− genotype was 67.7% (216/319). The total frequency of the oipA+ vs. oipA− genotypes in NAG, PUs, GC, non-peptic ulceration (including NAG and GC), and non-tumor (including NAG and PUs) groups was 121/172 (70.3%), 50/52 (96.2%), 45/95 (47.4%), 166/267 (62.2%), and 171/224 (76.3%), respectively. In multiple logistic regression analysis, the oipA+ vs. oipA− genotype showed a strong direct association with PUs; the ORadj (95% CI) was 18.751 (4.421–79.531), (p =0.00007). In contrast, it had a significant reverse association with GC; the ORadj (95% CI) was 0.330 (0.179–0.607), (p = 0.00036). In the present study, we interestingly found a contrasting association of the H. pylori oipA genotype with the risk of PUs and GC in Iran. Therefore, the contrasting effect of this genotype may emphasize its independent role in predicting clinical outcomes.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :ام البنین فعلی
نویسنده :سیده زهرا بختی
نویسنده مسئول :سعید لطیفی نوید
نویسنده :صابر ظاهری
نویسنده :عباس یزدانبد
ضریب تاثیر و نمایه مجلات:IF: 2.773 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):H.pylori oipA genotype Gastric cancer, peptic ulcerations
موضوعات :QW میکروب شناسی و ایمنی شناسی
WI سیستم گوارشی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :14005
ارائه شده توسط : دکتر عباس یزدانبد
ارائه شده در تاریخ :27 بهمن 1399 12:51
آخرین تغییر :27 بهمن 1399 12:51

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