پارسا خانکندی, حامد ، بهزاد, سحر ، صحرانورد, شمیم ، رضوانی, مینا ، تدریس حسنی, نغمه (1398) بررسی اثرات مهاری برخی از گیاهان دارویی روی تولید نیتریک اکساید در سلول های PC12 استرس دیده. Pharmaceutical Sciences ــ 25 (2). ص.ص.132-137. شاپا 1735-403X
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آدرس اینترنتی رسمی : https://ps.tbzmed.ac.ir/Article/Pharm-31731
عنوان انگليسی
Investigation of Some Medicinal Plants Inhibitory Effect on NO Production in Oxidative Stressed PC12 Cells
خلاصه انگلیسی
Background: Nitric oxide and reactive nitrogen species play an important role in various pathological conditions like cancer, inflammation and neurodegeneration. As plants and natural compounds have a great potency of discovering lead compounds which might affect NO production during inflammation and various pathologies, we examined the effects of three medicinal plants native to Iran, on NO production during oxidative stress in PC12 cells. Methods: In this study, cell death and NO levels were measured by MTT and by Griess assay, respectively. Oxidative stress was induced by hydrogen peroxide and extracts of Astragalus jolderensis, Convolvulus commutatus and Salvia multicaulis were used as pretreatment in oxidative stressed PC12 cells. Results: A. jolderensis extract significantly suppressed NO production in 150 and 200 μg/ml concentrations and C. commutatus extract in all concentration inhibited NO production in stressed PC12 cells. In addition, the extract of S. multicaulis inhibited NO production during stress at all concentrations above 50 μg/ml. Besides, the extract of S. multicaulis showed protective effect at lower doses in stressed cells. Conclusion: According to the results, S. multicaulis inhibited NO production and protected cells from oxidative stress. Hence, S. multicaulis is a good candidate for further in vitro and in vivo investigations. A. jolderensis and C. commutatus also suppressed NO production during stress. Therefore, they could be noticed in experiments that centralize on the inhibition of NO production and drug discovery studies in the field of neurodegenerative and chronic inflammatory diseases.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | حامد پارسا خانکندی |
نویسنده : | سحر بهزاد |
نویسنده مسئول : | شمیم صحرانورد |
نویسنده : | مینا رضوانی |
نویسنده : | نغمه تدریس حسنی |
ضریب تاثیر و نمایه مجلات: | Indexed in: Scopus, ESCI, Embase |
کلیدواژه ها (انگلیسی): | Nitric Oxide, PC12, Astragalus jolderensis, Convolvulus commutatus, Salvia multicaulis, Griess assay |
موضوعات : | QV فارماکولوژی > QV 752 فارماکوگنوزی QV فارماکولوژی > QV 766 گیاهان دارویی |
بخش های دانشگاهی : | دانشکده داروسازی > بخش فارماکوگنوزی |
کد شناسایی : | 14046 |
ارائه شده توسط : | دکتر حامد پارسا خانکندی |
ارائه شده در تاریخ : | 12 اسفند 1399 09:09 |
آخرین تغییر : | 12 اسفند 1399 09:09 |
فقط پرسنل کتابخانه صفحه کنترل اسناد