title

نقش ناقل گلوتامات-1 در فعالیت نورونی هسته لوکوس سرولئوس و درد در موش بزرگ آزمایشگاهی

نوزاد, عبدالله ، حمیدی, نسرین ، امانی, محمد (1399) نقش ناقل گلوتامات-1 در فعالیت نورونی هسته لوکوس سرولئوس و درد در موش بزرگ آزمایشگاهی. Experimental Brain Research ــ 239 (4). ص.ص.1287-1294. شاپا 0014-4819

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آدرس اینترنتی رسمی : https://link.springer.com/article/10.1007%2Fs00221...


عنوان انگليسی

The role of glutamate transporter-1 in firing activity of locus coeruleus neurons and nociception in rats

خلاصه انگلیسی

Locus coeruleus (LC) is considered to be the main source of norepinephrine in the central nervous system (CNS) and plays important role in relieving pain in the body. Changes in the activity of synaptic excitatory amino acid transporters (EAATs) would be an applicable way to regulate synaptic transmission in the LC. In the present study, we examined the role of astrocytic glutamate transporter-1 (GLT1) in the firing activity of LC neurons and the sensation of pain in rats. Male Wistar rats were divided into three control (CNT), ceftriaxone (CFT) and dihydrokainic acid (DHK) groups. Animals were given intraperitoneal injections for nine consecutive days after which the electrophysiological and behavioral experiments were performed to determine the single-unit activity of LC neurons and pain sensation. Results of this study revealed that CFT as a well-known up-regulator of GLT1 expression decreases the latency of pain sensation in rats but inhibition of GLT1 activity by DHK showed no significant effects. Furthermore, the results obtained by single-unit recording from LC showed a significant decrease in evoked response in CFT group compared to the CNT group. Therefore, this study suggests that GLT1 might be considered as a potential therapeutic target for pain modulation in the future.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :عبدالله نوزاد
نویسنده :نسرین حمیدی
نویسنده مسئول :محمد امانی
ضریب تاثیر و نمایه مجلات:IF: 2 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Ceftriaxone; GLT1; Locus coeruleus; Nociception; Single unit recording
موضوعات :QT فیزیولوژی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی
کد شناسایی :14120
ارائه شده توسط : خانم صغری گلمغانی
ارائه شده در تاریخ :25 اسفند 1399 13:44
آخرین تغییر :01 مرداد 1402 09:21

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