title

یک مرور سیستماتیک و متاآنالیز به روز شده در مورد مقاومت آنتی بیوتیکی مایکوباکتریوم توبرکلوزیس در ایران (2013-2020)

خادمی, فرزاد and صاحبکار, امیر حسین (1400) یک مرور سیستماتیک و متاآنالیز به روز شده در مورد مقاومت آنتی بیوتیکی مایکوباکتریوم توبرکلوزیس در ایران (2013-2020). Iranian Journal of Basic Medical Sciences ــ 24 (4). pp. 428-436. شاپا 2008-3866

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Title

An updated systematic review and meta-analysis on Mycobacterium tuberculosis antibiotic resistance in Iran (2013- 2020)

English Abstract

This updated systematic review and meta-analysis follows two aims: 1) to assess Mycobacterium tuberculosis (M. tuberculosis) antibiotic resistance in Iran from 2013 to 2020 and, 2) to assess the trend of resistance from 1999 to 2020. Several national and international databases were systematically searched through MeSH extracted keywords to identify 41 published studies addressing drug-resistant M. tuberculosis in Iran. Meta-analysis was done based on the PRISMA protocols using Comprehensive Meta-Analysis software. The average prevalence of resistance to first- and second-line anti-TB drugs, multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) in new and previously treated tuberculosis (TB) cases in Iran during 2013–2020 were as follows: isoniazid 6.9%, rifampin 7.9%, ethambutol 5.7%, pyrazinamide 20.4%, para-aminosalicylic acid 4.6%, capreomycin 1.7%, cycloserine 1.8%, ethionamide 11.3%, ofloxacin 1.5%, kanamycin 3.8%, amikacin 2.2%, MDR-TB 6.3% and XDR-TB 0.9%. Based on the presented data, M. tuberculosis resistance to first- and second-line anti-TB drugs, as well as MDR-TB, was low during 2013–2020 in Iran. Furthermore, there was a declining trend in TB drug resistance from 1999 to 2020. Hence, to maintain the current decreasing trend and to control and eliminate TB infection in Iran, continuous monitoring of resistance patterns is recommended.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :فرزاد خادمی
نویسنده :امیر حسین صاحبکار
Additional Information:IF: 2.146 Indexed in: ISI, Scopus, PubMed/PMC, Embase
کلیدواژه ها (انگلیسی):Antibiotic Iran Meta ; analysis Mycobacterium tuberculosis Resistance
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:14130
Deposited By: Dr Farzad Khademi
Deposited On:24 Jan 1400 11:41
Last Modified:24 Jan 1400 11:41

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