بررسی مکانیسم هایی که اثرات مفید ورزش بر مغز و عملکردهای شناختی را واسطه گری می کند.

مشهدی, زهرا and سعادتی, حکیمه and دادخواه, معصومه (1400) بررسی مکانیسم هایی که اثرات مفید ورزش بر مغز و عملکردهای شناختی را واسطه گری می کند. international journal of medical reviews ــ 8 (1). pp. 45-56. شاپا 2345-525X


Official URL: http://www.ijmedrev.com/article_128416.html


Investigating the Putative Mechanisms Mediating the Beneficial Effects of Exercise on the Brain and Cognitive Functions

English Abstract

Introduction: Exercise training is documented to impact many aspects of brain function and has helpful effects on the overall brain, mental health, and performance. The beneficial impacts of exercise on brain performances are the promotion of learning and memory, enhancement of plasticity, protection from neurodegenerative disease, and neuro-rehabilitation following stroke. Methods: Searching keywords including cognitive functions, exercise, neurodegenerative diseases, neurotrophic factors, and sleep deprivation in Pubmed, Science Direct, and Google Scholar helped us to access approximately 153 articles in this study. Besides, the positive effects of various forms of exercise on the brain function in humans and animal experiments mediated by neurotrophic factors were compared and discussed in this review. Results: Regular physical activity increases synaptic plasticity by influencing the synaptic organization and potentiating synaptic strength and enhances the expression of certain neurotrophic factors including Brain-Derived Neurotrophic Factor (BDNF) which is the key mechanism intermediating wide benefits of exercise in the brain and animal hippocampus. In addition, exercise improves synaptic plasticity by reinforcing the underlying systems which support plasticity including neurogenesis, metabolism, and angiogenesis. Such structural and functional alteration made by physical activities has been indicated in various parts of the brain. These alternations have been studied more in the hippocampal system. Conclusion: A variety of brain disorders including alzheimer's disease, parkinson's disease, chronic stress, age-related cognitive decline, psychological disorders have been revealed to avoid, restore, or improve by different procedures of physical exercise.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :زهرا مشهدی
نویسنده مسئول :حکیمه سعادتی
نویسنده :معصومه دادخواه
Additional Information:Indexed in: Google scholar, SID , Magiran
کلیدواژه ها (انگلیسی):Cognitive Functions, Exercise, Neurodegenerative Diseases, Neurotrophic Factors
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:14146
Deposited By: Dr. Hakimeh Saadati
Deposited On:24 Jan 1400 12:00
Last Modified:24 Jan 1400 12:00

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