لوسمی الوکمیک با تابلوی پلی ارتریت و شکستگی متعدد: گزارش موردی

عنوان انگليسی

Aleukemic Leukemia presenting with polyarthritis and pathological fractures: A Case Report

خلاصه انگلیسی

Introduction: About %30 of patients with leukemia initially present with musculoskeletal signs and symptoms as medullary involvement including limping , bone or joint pain and fractures. Case presentation: The patient was a 10 year old boy that present with polyarthritis and pathological fracture of his wrist and vertebral body bones. Peripheral blood test revealed no abnormal cells, bone biopsy at the fracture site only showed small aggregates of unremarkable lymphocytes. A bone marrow study couldn't provide a definitive diagnosis of acute leukemia on morphology and immunohistochemistry. A diagnosis of precursor B-cell ALL was unequivocally confirmed by bone marrow biopsy. Conclusion: ALL is the commonest childhood cancer, accounting for up to one third of all pediatric malignancies. Common presentations include; fever, bleeding and lymphadenopathy, while about 30presented of patients with bone or joint pain. However, musculoskeletal symptoms can be the only presenting feature of ALL, causing a delay in diagnosis.

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