بررسی اثرمتقابل بین عفونت هلیکوباکتر پیلوری (Hp) و سایر عوامل خطر سرطان معده: تجزیه و تحلیل تلفیقی در پروژه تجمع سرطان معده (StoP)

Rota, M. and Alicandro, G. and Pelucchi, C. and Bonzi, R. and Bertuccio, P. and Hu, J. and Zhang, Zuo-Feng and Johnson, K.C. and Palli, D. and Ferraroni, M. and Yu, G.-P. and Galeone, C. and López-Carrillo, L. and Muscat, J. and Lunet, N. and Ferro, A. and Ye, W. and Plymoth, A. and ملک زاده, رضا and Zaridze, D. and Maximovitch, D. and Kogevinas, M. and Fernández de Larrea, N. and Vioque, J. and Navarrete-Muñoz, E.M. and Tsugane, S. and Hamada, G.S. and Hidaka, A. and Pakseresht, M. and Wolk, A. and HÃ¥kansson, N. and Hernández-Ramírez, R.U. and López-Cervantes, M. and Ward, M. and پورفرضی, فرهاد and Mu, L. and Kurtz, R.C. and Lagiou, A. and Lagiou, P. and Boffetta, P. and Boccia, S. and Negri, E. and La Vecchia, C. (1400) بررسی اثرمتقابل بین عفونت هلیکوباکتر پیلوری (Hp) و سایر عوامل خطر سرطان معده: تجزیه و تحلیل تلفیقی در پروژه تجمع سرطان معده (StoP). International Journal of Cancer ــ 146 (3). pp. 671-681. شاپا 00207136

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Exploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project

English Abstract

Helicobacter pylori (Hp) is crucial in gastric carcinogenesis, but infection alone is not a sufficient cause, and the interaction between Hp infection and other risk factors has not been adequately studied. We conducted a pooled analysis of seven case-control studies from the Stomach cancer Pooling (StoP) Project, comprising 1377 cases and 2470 controls, to explore the interaction among Hp infection and tobacco smoking, alcohol drinking, socioeconomic status (SES) and dietary salt intake on the risk of gastric cancer. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by multivariate unconditional logistic regression. The analysis showed no consistent interaction between Hp infection and cigarette smoking, while interaction was more than multiplicative for alcohol drinking (OR = 1.38, 95% CI: 1.07-1.77, P-interaction 0.02) and high intake of salt (OR = 2.62, 95% CI: 1.88-3.65, P-interaction = 0.04). The interaction with SES followed the multiplicative model (P = 0.49), resulting in a weakening among infected individuals of the protective effect of high SES among observed Hp-negative individuals. The interactions found were more pronounced in subjects with history of peptic ulcer. The interactions with Hp infection were stronger for cigarette smoking and dietary salt in the case of noncardia cancer, and for alcohol and SES in the case of cardia cancer. No differences were found when stratifying for histologic type. This large-scale study aimed to quantify the interaction between Hp infection and other modifiable risk factors of gastric cancer revealed that the benefit of combined Hp eradication and lifestyle modification on gastric cancer prevention may be larger than commonly appreciated

Item Type:Article
زبان سند : انگلیسی
نویسنده :رضا ملک زاده
نویسنده :فرهاد پورفرضی
Additional Information:IF: 7.396 Indexed in: ISI, PubMed/Medline, Scopus, Embase
Uncontrolled Keywords:age; Article; Asia; cancer risk; cigarette smoking; drinking behavior; educational status; Europe; family history; food intake; fruit; Helicobacter infection; high risk population; household income; human; priority journal; sex; stomach cancer; systematic review; vegetable; Western Hemisphere; adult; aged; case control study; female; health disparity; Helicobacter infection; Helicobacter pylori; incidence; income; information processing; isolation and purification; male; meta analysis; microbiology; middle aged; North America; risk assessment; risk factor; stomach mucosa; stomach tumor; vulnerable population, Adult; Aged; Asia; Case-Control Studies; Datasets as Topic; Educational Status; Europe; Female; Gastric Mucosa; Health Status Disparities; Helicobacter Infections; Helicobacter pylori; Humans; Incidence; Income; Male; Middle Aged; North America; Risk Assessment; Risk Factors; Stomach Neoplasms; Vulnerable Populations
Subjects:QY Clinical Pathology
WI Digestive System
Divisions:Vice Chancellor for Research and Technology > Digestive Disease Research Center
ID Code:14306
Deposited By: MS Soghra Golmaghani
Deposited On:11 Sep 1400 11:12
Last Modified:08 Nov 1401 11:16

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