خادمی, فرزاد ، صاحبکار, امیر حسین (1400) آیا استرپتوکوکوس پنومونیه غیر حساس به پنی سیلین چالش مهمی برای سیستم بهداشتی است؟ یک مرور سیستماتیک و متاآنالیز. Scientifica ــ 2021 (557334). ص.ص.1-12. شاپا 2090-908X
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آدرس اینترنتی رسمی : https://www.hindawi.com/journals/scientifica/2021/...
عنوان انگليسی
Is Penicillin-Nonsusceptible Streptococcus pneumoniae a Significant Challenge to Healthcare System? A Systematic Review and Meta-Analysis
خلاصه انگلیسی
Background. In recent years, antibiotic-resistant pathogens including penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) have posed serious threats against human health. The aim of this meta-analysis was to investigate the prevalence of Streptococcus pneumoniae drug resistance particularly the incidence of PNSP strains in Iran. Methods. A systematic search was done in national and international electronic databases using Persian and English keywords. Up until May 20, 2020, a total of 58 publications were detected as eligible articles based on the inclusion and exclusion criteria, and then the selected studies were enrolled for data extraction and meta-analysis according to the PRISMA guidelines. Results. A high rate of PNSP (46.9%) and multidrug-resistant (MDR) S. pneumoniae (45.3%) in our isolates were evident. Furthermore, total frequency resistance to other drugs in S. pneumoniae was as follows: erythromycin 41.1%, azithromycin 53.2%, tetracycline 39.9%, levofloxacin 1.7%, rifampin 1.2%, clindamycin 31.7%, vancomycin 1.7%, trimethoprim/sulfamethoxazole 63.9%, chloramphenicol 20%, ceftriaxone 10.9%, amoxicillin 30.5%, ciprofloxacin 8.3%, imipenem 6.1%, linezolid 0%, and cefotaxime 8.3%. Conclusion. Although the overall prevalence of cephalosporin- and carbapenem-resistant Streptococcus pneumoniae was low, penicillin-resistant strains, especially PNSP, could become a significant challenge to the healthcare system in Iran. Hence, the prescription of penicillin as the first-choice antibiotic in the treatment of S. pneumoniae infections should be avoided.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | فرزاد خادمی |
نویسنده مسئول : | امیر حسین صاحبکار |
ضریب تاثیر و نمایه مجلات: | Indexed in: Scopus, ESCI, PubMed/PMC, DOAJ |
کلیدواژه ها (انگلیسی): | Antibiotic resistance; Streptococcus pneumoniae; penicillin; Iran |
موضوعات : | QW میکروب شناسی و ایمنی شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی |
کد شناسایی : | 14398 |
ارائه شده توسط : | دکتر فرزاد خادمی |
ارائه شده در تاریخ : | 21 تیر 1400 07:16 |
آخرین تغییر : | 21 تیر 1400 07:16 |
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