نقش های برجسته میکرو آر ان ای- 142 در سرطان

پهلوان, یاسمین and محمدی نصر, مینا and دلیر عبدالهی نیا, الهه and پیردل, زهرا and رازی صوفیانی, سعیده and سیاهپوش, سمانه and نجاتی کوشکی, کاظم (1399) نقش های برجسته میکرو آر ان ای- 142 در سرطان. Pathology - Research and Practice ــ 216 (11). p. 153220. شاپا 0344-0338

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Prominent roles of microRNA-142 in cancer

English Abstract

MicroRNAs (miRNAs) are single-stranded non-coding RNAs that regulate gene expression post-transcriptionally via mRNA degradation, or translational repression. They have important roles in normal development and homeostasis maintenance. Many studies have revealed that aberrant expression of miRNAs is associated with development of pathological conditions, including cancers. MiRNAs can either promote or suppress tumorigenesis based on the regulation of gene expression by targeting multiple molecules. In recent years, several miRNAs have been reported to be dysregulated in various cancers. Most recent findings have shown that miR-142 gene, located at chromosome 17q22, is involved in cellular migration, proliferation, and apoptosis in different human cancers. The present review discusses some molecular mechanisms and the expression status of miRNA-142 in the pathogenesis of various cancers.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :یاسمین پهلوان
نویسنده :مینا محمدی نصر
نویسنده :الهه دلیر عبدالهی نیا
نویسنده :زهرا پیردل
نویسنده :سعیده رازی صوفیانی
نویسنده :سمانه سیاهپوش
نویسنده مسئول :کاظم نجاتی کوشکی
Additional Information:IF: 2.050 Indexed in:ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Metastasis, Invasion, Cancer, miRNA-142, Malignancies
Subjects:QZ Pathology
WB Practice of Medicine
Divisions:Vice Chancellor for Research and Technology > Pharmaceutical Sciences Research Center
ID Code:14448
Deposited By: Dr Kazem Nejati
Deposited On:31 Mar 1400 11:19
Last Modified:23 Nov 1401 10:52

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