تمرکز بیشتر بر روی سلول های گلیال در بهبودی بهتر پس از آسیب نخاعی

حسن زاده, سجاد and جالسی, مریم and جامعی, سید بهنام الدین and خان محمدی, مهدی and باقر, زهره and نامجو, زینب and داواچی, سیدمحمد (1400) تمرکز بیشتر بر روی سلول های گلیال در بهبودی بهتر پس از آسیب نخاعی. Biochemistry and Biophysics Reports ــ 25 . p. 100905. شاپا 2405-5808

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Official URL: https://www.sciencedirect.com/journal/biochemistry...


More attention on glial cells to have better recovery after spinal cord injury

English Abstract

Functional improvement after spinal cord injury remains an unsolved difficulty. Glial scars, a major component of SCI lesions, are very effective in improving the rate of this recovery. Such scars are a result of complex interaction mechanisms involving three major cells, namely, astrocytes, oligodendrocytes, and microglia. In recent years, scientists have identified two subtypes of reactive astrocytes, namely, A1 astrocytes that induce the rapid death of neurons and oligodendrocytes, and A2 astrocytes that promote neuronal survival. Moreover, recent studies have suggested that the macrophage polarization state is more of a continuum between M1 and M2 macrophages. M1 macrophages that encourage the inflammation process kill their surrounding cells and inhibit cellular proliferation. In contrast, M2 macrophages promote cell proliferation, tissue growth, and regeneration. Furthermore, the ability of oligodendrocyte precursor cells to differentiate into adult oligodendrocytes or even neurons has been reviewed. Here, we first scrutinize recent findings on glial cell subtypes and their beneficial or detrimental effects after spinal cord injury. Second, we discuss how we may be able to help the functional recovery process after injury.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :سجاد حسن زاده
نویسنده :مریم جالسی
نویسنده :سید بهنام الدین جامعی
نویسنده :مهدی خان محمدی
نویسنده :زهره باقر
نویسنده :زینب نامجو
نویسنده :سیدمحمد داواچی
Additional Information:Indexed in: Scopus, PubMed/PMC, Embase
Uncontrolled Keywords:ضایعه طناب نخاعی، آستروسیت A1، آستروسیت A2 ، OPCs، ماکروفاژ M1 و M2
کلیدواژه ها (انگلیسی):Spinal cord injury , A1 astrocyte , A2 astrocyte OPCs , M1 and M2 macrophages
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:14831
Deposited By: Dr Zeinab Namjoo
Deposited On:24 Dec 1400 07:59
Last Modified:24 Dec 1400 08:05

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