سولفور اکسید مرگ سلولی هیپوکمپ را کاهش داده و نارسایی های یادگیری و حافظه در مدل ایسکمی گلوبال را بهبود می بخشد.

زارع مهرجردی, فاطمه and شوشتری, علی and محسنی, فهیمه and خواستار, حسین and نوروزی, پیراسته and اسدی, یاسین and دادخواه, معصومه and خاکساری, مهدی (1397) سولفور اکسید مرگ سلولی هیپوکمپ را کاهش داده و نارسایی های یادگیری و حافظه در مدل ایسکمی گلوبال را بهبود می بخشد. Iranian Journal of Basic Medical Sciences ــ 21 (10). pp. 998-1003. شاپا 2008-3866


Official URL: https://ijbms.mums.ac.ir/article_11363.html


Sulfur dioxide reduces hippocampal cells death and improves learning and memory deficits in rat model of transient global ischemia/reperfusion

English Abstract

Objective(s): According to recent the findings, sulfur dioxide (SO2) is produced by the cardiovascular system, influencing some major biological processes. Based on previous research, SO2 exhibits antioxidant effects and inhibits apoptosis following cardiac ischemia/reperfusion. Therefore, the objective of the current study was to examine the neuroprotective impact of SO2 following global cerebral ischemia/reperfusion (I/R). Materials and Methods: Forty-eight male Wistar rats that weighed 260–300 g, were randomly allocated into 4 groups: sham group (n=12), I/R group (n=12), and I/R+SO2 groups (NaHSO3 and Na2SO3; 1:3 ratio; 5 and 10 µg/kg, respectively; for 3 days, n=12). Cerebral ischemia model was prepared by occlusion of both common carotid arteries for 20 min. Saline as a vehicle and SO2 donor at doses 5 µg/kg (intraperitoneally) were injected for 3 days after reperfusion. Four days after ischemia, the passive avoidance memory test was carried out in four groups, and after behavioral assessment, necrosis, apoptosis, and antioxidant enzyme analysis were carried out. Results: SO2 treatment could significantly improve memory impairments in rats with cerebral ischemia/reperfusion (I/R) (P<0.05). An increase in both superoxide dismutase and glutathione and a reduction in malondialdehyde were reported in the SO2 group versus the ischemic group (P<0.05). Moreover, SO2 could significantly decrease necrotic and apoptotic cells in the CA1 region (P<0.01). Conclusion: According to the findings, SO2 exerts significant neuroprotective effects on cerebral I/R due to its antioxidant activity.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فاطمه زارع مهرجردی
نویسنده :علی شوشتری
نویسنده :فهیمه محسنی
نویسنده :حسین خواستار
نویسنده :پیراسته نوروزی
نویسنده :یاسین اسدی
نویسنده :معصومه دادخواه
نویسنده مسئول :مهدی خاکساری
Additional Information:IF: 1.854 Indexed in: ISI, Scopus, PubMed, Embase
Uncontrolled Keywords:فعالیت آنتی اکسیدانی آپوپتوزیس ایسکمی مغزی حافظه سولفور دی اکسید
کلیدواژه ها (انگلیسی):Antioxidant activity Apoptosis Brain ischemia Memory Sulfur dioxide
Subjects:QT physiology
WL Nervous system
Divisions:Vice Chancellor for Research and Technology > Pharmaceutical Sciences Research Center
ID Code:15038
Deposited By: Dr Masoumeh Dadkhah
Deposited On:01 Oct 1400 07:32
Last Modified:01 Oct 1400 07:32

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