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ایمونولوژی سارس کووید 2: درمان بر پایه آنتی بادی و استراتژی های واکسیناسیون

پاینده, زهرا ، محمد خانی, نیلوفر ، نبی, محسن ، خلیلی, سعید ، رجبی بذل, معصومه ، هوجاقانی, زهرا ، دادخواه, معصومه (1399) ایمونولوژی سارس کووید 2: درمان بر پایه آنتی بادی و استراتژی های واکسیناسیون. Expert Review of Anti-infective Therapy ــ 19 (7). ص.ص.899-910. شاپا 1478-7210

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آدرس اینترنتی رسمی : https://www.tandfonline.com/doi/full/10.1080/14787...


عنوان انگليسی

The immunology of SARS-CoV-2 infection, the potential antibody based treatments and vaccination strategies

خلاصه انگلیسی

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a potentially fatal agent for a new emerging viral disease (COVID-19) is of great global public health emergency. Herein, we represented potential antibody based treatments especially monoclonal antibodies (mAbs) that may exert a potential role in treatment as well as developing vaccination strategies against COVID-19. We used PubMed, Google Scholar, and clinicaltrials.gov search strategies for relevant papers. We demonstrated some agents with potentially favorable efficacy as well as favorable safety. Several therapies are under assessment to evaluate their efficacy and safety for COVID19. However, development of different strategies such as SARS-CoV-2-based vaccines and antibody therapy are urgently required beside other effective therapies such as plasma, anticoagulants, and immune as well as antiviral therapies. We encourage giving more attention to antibody based treatments as an immediate strategy. Although, there has not been any approved specific vaccine until now, developing vaccination strategies may have a protective effect against COVID-19. An antiviral mAbs could be a safe and high-quality therapeutic intervention which is greatly recommended for COVID-19. Additionally, the high sequence homology between the SARS-CoV-2 and SARS/MERS viruses, could shed light on developing to design a vaccine against SARS-CoV-2.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :زهرا پاینده
نویسنده :نیلوفر محمد خانی
نویسنده :محسن نبی
نویسنده :سعید خلیلی
نویسنده :معصومه رجبی بذل
نویسنده :زهرا هوجاقانی
نویسنده مسئول :معصومه دادخواه
ضریب تاثیر و نمایه مجلات:IF: 4.921 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):OVID-19, antibody therapy, vaccine, monoclonal
موضوعات :WC بیماریهای واگیر
بخش های دانشگاهی :معاونت تحقیقات و فناوری > مرکز تحقیقاتی علوم دارویی
کد شناسایی :15039
ارائه شده توسط : دکتر معصومه دادخواه
ارائه شده در تاریخ :10 آبان 1401 13:02
آخرین تغییر :10 آبان 1401 13:02

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