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قرارگیری در محیط غنی شده در دوره نوجوانی اختلال شناختی موشهای نر محروم از خواب را بهبود می بخشد. نقش فاکتور نوروتروفیک مشتق از مغز

قاهری, صفا ، پناهپور, حمداله ، عبداله زاده, مریم ، سعادتی, حکیمه (1400) قرارگیری در محیط غنی شده در دوره نوجوانی اختلال شناختی موشهای نر محروم از خواب را بهبود می بخشد. نقش فاکتور نوروتروفیک مشتق از مغز. International Journal of Developmental Neuroscience ــ . شاپا 0736-5748 (در حال چاپ )

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آدرس اینترنتی رسمی : https://onlinelibrary.wiley.com/doi/10.1002/jdn.10...


عنوان انگليسی

Adolescent enriched environment exposure alleviates cognitive impairments in sleep-deprived male rats: Role of hippocampal brain-derived neurotrophic factor

خلاصه انگلیسی

Developmental life experience has long-lasting influences on the brain and behavior. The present study aims to examine the long-term effects of the enriched environment (EE), which was imposed during the adolescence period of life, on their passive avoidance and recognition memories as well as anxiety-like behaviors and hippocampal brain-derived neurotrophic factor (BDNF) levels, in sleep-deprived male rats. In the present study, the male pups were separated from their mothers in postnatal day 21 (PND21) and were housed in the standard or EE for 40 days. In PND 61, the rats were allocated in four groups: control, SD (sleep deprivation), EE, and EE + SD groups. SD was induced in rats by a modified multiple platform model for 24 h. Open field, novel object recognition memory, and passive avoidance memory tests were used to examine behavior and cognitive ability. The expression of hippocampal BDNF levels was determined by PCR. The results revealed that SD increased anxiety-like behaviors and impaired cognitive ability, while adolescent EE housing alleviated these changes. In addition, EE reversed SD-induced changes in hippocampal BDNF level. We also demonstrated that EE not only has beneficial effects on the cognitive functions of normal rats but also declined memory deficits induced by SD. In conclusion, our results suggest that housing in EE during the adolescence period of life reduces cognitive impairment induced by SD. The increase of the BDNF level in the hippocampus is a possible mechanism to alleviate cognitive performance in sleep-deprived rats.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :صفا قاهری
نویسنده :حمداله پناهپور
نویسنده :مریم عبداله زاده
نویسنده مسئول :حکیمه سعادتی
ضریب تاثیر و نمایه مجلات:IF: 2.457 Indexed in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):Anxiety,BDNF,Enriched environment, Memory، Sleep deprivation
موضوعات :QT فیزیولوژی
WL سیستم عصبی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی
کد شناسایی :15235
ارائه شده توسط : دکتر حکیمه سعادتی
ارائه شده در تاریخ :27 بهمن 1400 08:23
آخرین تغییر :27 بهمن 1400 08:23

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