قرارگیری در محیط غنی شده در دوره نوجوانی اختلال شناختی موشهای نر محروم از خواب را بهبود می بخشد. نقش فاکتور نوروتروفیک مشتق از مغز

قاهری, صفا and پناهپور, حمداله and عبداله زاده, مریم and سعادتی, حکیمه (1400) قرارگیری در محیط غنی شده در دوره نوجوانی اختلال شناختی موشهای نر محروم از خواب را بهبود می بخشد. نقش فاکتور نوروتروفیک مشتق از مغز. International Journal of Developmental Neuroscience ــ . شاپا 0736-5748 (In Press)

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Adolescent enriched environment exposure alleviates cognitive impairments in sleep-deprived male rats: Role of hippocampal brain-derived neurotrophic factor

English Abstract

Developmental life experience has long-lasting influences on the brain and behavior. The present study aims to examine the long-term effects of the enriched environment (EE), which was imposed during the adolescence period of life, on their passive avoidance and recognition memories as well as anxiety-like behaviors and hippocampal brain-derived neurotrophic factor (BDNF) levels, in sleep-deprived male rats. In the present study, the male pups were separated from their mothers in postnatal day 21 (PND21) and were housed in the standard or EE for 40 days. In PND 61, the rats were allocated in four groups: control, SD (sleep deprivation), EE, and EE + SD groups. SD was induced in rats by a modified multiple platform model for 24 h. Open field, novel object recognition memory, and passive avoidance memory tests were used to examine behavior and cognitive ability. The expression of hippocampal BDNF levels was determined by PCR. The results revealed that SD increased anxiety-like behaviors and impaired cognitive ability, while adolescent EE housing alleviated these changes. In addition, EE reversed SD-induced changes in hippocampal BDNF level. We also demonstrated that EE not only has beneficial effects on the cognitive functions of normal rats but also declined memory deficits induced by SD. In conclusion, our results suggest that housing in EE during the adolescence period of life reduces cognitive impairment induced by SD. The increase of the BDNF level in the hippocampus is a possible mechanism to alleviate cognitive performance in sleep-deprived rats.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :صفا قاهری
نویسنده :حمداله پناهپور
نویسنده :مریم عبداله زاده
نویسنده مسئول :حکیمه سعادتی
Additional Information:IF: 2.457 Indexed in: ISI, Scopus, PubMed/Medline, Embase
کلیدواژه ها (انگلیسی):Anxiety,BDNF,Enriched environment, Memory، Sleep deprivation
Subjects:QT physiology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:15235
Deposited By: Dr. Hakimeh Saadati
Deposited On:27 Nov 1400 08:23
Last Modified:27 Nov 1400 08:23

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