متیل سولفونیل متان از طریق مهار استرس اکسیداتیو، واسطه های پیش التهابی و مرگ سلولی آپوپتوز در برابر آسیب مغزی ناشی از اتانول در موش محافظت می کند

امیرشاهرخی, کیوان and نیاپور, علی (1401) متیل سولفونیل متان از طریق مهار استرس اکسیداتیو، واسطه های پیش التهابی و مرگ سلولی آپوپتوز در برابر آسیب مغزی ناشی از اتانول در موش محافظت می کند. International Immunopharmacology ــ 106 (108638). pp. 1-11. شاپا 1567-5769

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Methylsulfonylmethane protects against ethanol-induced brain injury in mice through the inhibition of oxidative stress, proinflammatory mediators and apoptotic cell death

English Abstract

Excessive ethanol consumption causes brain injury through oxidative stress, inflammation and apoptotic cell death. Methylsulfonylmethane (MSM) is a natural compound that has therapeutic effects on oxidative and inflammatory disorders. The aim of this study was to investigate the protective effect and underlying mechanisms of MSM on ethanol-induced brain injury in an experimental model. Male C57BL/6 mice were exposed to binge ethanol (5 g/kg/day, orally) and treated with MSM (200 and 400 mg/kg/day) concomitantly for 12 days. At the end of the experiment brain tissues were removed for histological and biochemical analysis. The results showed that MSM reduced ethanol-mediated oxidative stress by decreasing the levels of malondialdehyde (MDA) and carbonyl protein. The Nrf2/HO-1 pathway and the levels of cytoprotective antioxidants superoxide dismutase (SOD), catalase and glutathione (GSH) were increased by MSM in the brain tissue. MSM treatment reduced the ethanol-induced inflammatory factors including myeloperoxidase (MPO), iNOS/NO, cyclooxygenase (COX)-2, nuclear factor kappa B (NF-κB), NLRP3 inflammasome and proinflammatory cytokines including TNF-α, IL-1β, IL-6 and MCP-1. MSM also decreased the levels of pro-apoptotic caspase-3 and TUNEL positive cells while increased the level of anti-apoptotic Bcl-2 in the brain tissue. Our findings demonstrated that MSM protects against ethanol-induced brain injury by improving anti-oxidant defense mechanism and reducing ethanol-mediated inflammation and apoptosis. Therefore, MSM may be a potential protective approach for brain damage caused by high levels of alcohol.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :علی نیاپور
Additional Information:IF: 5.714 Indexed in:ISI, PubMed/Medline, Scopus
کلیدواژه ها (انگلیسی):Ethanol, Brain injury, Methylsulfonylmethane, Inflammation, Apoptosis, Oxidative stress
Subjects:QV pharmacology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
School of Pharmacy > Department of Pharmacology
ID Code:15348
Deposited By: Dr Ali Niapour
Deposited On:24 Feb 1401 08:41
Last Modified:08 May 1401 12:35

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