فعال‌سازی گیرنده گاباA پس از تولد، انعطاف سیناپسی و شناخت را در موش‌های صحرایی بالغ ویستار تغییر می‌دهد.

امانی, محمد and محمدیان, فروزان and گلی طبری, نسترن and سالاری, علی اکبر (1401) فعال‌سازی گیرنده گاباA پس از تولد، انعطاف سیناپسی و شناخت را در موش‌های صحرایی بالغ ویستار تغییر می‌دهد. Molecular Neurobiology ــ 59 (6). pp. 3585-3599. شاپا 0893-7648

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Official URL: https://link.springer.com/article/10.1007/s12035-0...


Postnatal GABA(A) Receptor Activation Alters Synaptic Plasticity and Cognition in Adult Wistar Rats

English Abstract

Early life alteration in the activity of gamma-aminobutyric acid (GABA) receptors is associated with long-lasting developmental effects on the brain and behavior. GABAA receptors act as excitatory rather than inhibitory in neonates. Excessive activation of GABAA receptors during the early postnatal period may affect cognitive functions later in life. In this study, we sought to determine whether neonatal activation of GABAA receptors with muscimol can alter the electrophysiology profile of hippocampal CA1 neurons and spatial learning and memory in adult rats. Male and female Wistar rat pups received a subcutaneous injection of either saline or muscimol (500 µg/kg) on postnatal days (PND) 7, 9, and 11 and then underwent different electrophysiology and behavioral experiments in adulthood. Early life treatment with muscimol did not alter the basic synaptic transmission but significantly reduced the paired-pulse facilitation (PPF) in the CA1 area. Neonatal application of muscimol led to a pronounced decrease in long-term potentiation (LTP) and long-term depression (LTD) in CA1 neurons along with a declined theta-burst responses in both sexes. We obtained some evidence that neonatal GABAA activation leads to reduced brain-derived neurotrophic factor (BDNF) in the hippocampus and prefrontal cortex. Our electrophysiology data was supported with spatial reference and working memory deficits in rats. This study provides the first detailed description of altered electrophysiology in hippocampal CA1 neurons in adult rats undergone GABAA activation early in life.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :محمد امانی
نویسنده :فروزان محمدیان
نویسنده :نسترن گلی طبری
نویسنده :علی اکبر سالاری
Additional Information:IF: 5.59 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Early life; GABAA activation; Learning and memory; Synaptic plasticity
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:15863
Deposited By: Dr Mohammad Amani
Deposited On:09 Mar 1401 08:20
Last Modified:09 Mar 1401 08:20

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