حبیب زاده, نسرین ، پیری دوگاهه, هادی ، منوچهری فر, میثم ، علیمحمدی, حسین ، ایرانپور, سهراب ، ارزنلو, محسن (1401) حاملی روده ای انتروباکتریال های مولد بتالاکتامازهای وسیع الطیف و AmpC پلاسمیدی در یک جامعه ایرانی: شیوع، فاکتورهای خطر، اپیدمیولوژی مولکولی و مقاومت آنتی بیوتیکی. Microbial Drug Resistance ــ 28 (9). ص.ص.1-14. شاپا 1076-6294
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آدرس اینترنتی رسمی : https://www.liebertpub.com/doi/abs/10.1089/mdr.202...
عنوان انگليسی
Fecal Carriage of Extended-Spectrum b-Lactamases and pAmpC Producing Enterobacterales in an Iranian Community: Prevalence, Risk Factors, Molecular Epidemiology, and Antibiotic Resistance
خلاصه انگلیسی
This study aimed to determine the prevalence and risk factors associated with intestinal carriage of extendedspectrum b-lactamases producing Enterobacterales (ESBL-PE) and plasmid-mediated AmpC b-lactamase producing Enterobacterales (AmpC-PE) in healthy children in Ardabil, Iran. A total of 305 fecal samples were collected. Isolates underwent antimicrobial susceptibility testing, phenotypic and genotypic identification of blactamase production, and epidemiologic molecular typing. In total, 21.5%, 1.5%, and 1.2% of volunteers were extended-spectrum b-lactamase (ESBL)-, AmpC-, and simultaneous ESBL/AmpC-PE carriers, respectively. Escherichia coli was the predominant ESBL producing bacterium (70.2%) found in ESBL-PE colonized subjects. Beyond ESBL positive isolates, bla CTX-M group genes were the most common type (75.6%) and bla TEM (non-bla TEM-1 and non- bla TEM-2) were in the second place (25.6%). Among bla CTX-M genes, bla CTXM-1 (55.3%) and bla CTX-M-15 (55.3%) were the most predominant types with equal prevalence. Some isolates were multi-enzyme producers. bla CIT and bla DHA genes were common AmpC type enzyme encoding genes found in AmpC-PE isolates. Most isolates produced both enzymes at the same time. The number of students in the classes was statistically associated with ESBL-PE intestinal carriage ( p < 0.05). Moreover, 46 (65.7%), 3 (60%), 4 (100%), and 98 (39.8%) ESBL-, AmpC-, ESBL/AmpC, and non-ESBL/AmpC-PE isolates were multidrug-resistant, respectively. Overall, regardless of b-lactam antibiotics, 62% and 59.5% of isolates were resistant to co-trimoxazole and tetracycline, respectively. The majority of ESBL producing E. coli isolates (69.2%) belonged to phylogroup A. According to Enterobacterial repetitive intergenic consensus polymerase chain reaction, there was no clonal relatedness between isolates. This study showed a high rate of multi-resistant ESBL-PE intestinal carriage among healthy individuals in Iran.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | نسرین حبیب زاده |
نویسنده : | هادی پیری دوگاهه |
نویسنده : | میثم منوچهری فر |
نویسنده : | حسین علیمحمدی |
نویسنده : | سهراب ایرانپور |
نویسنده مسئول : | محسن ارزنلو |
ضریب تاثیر و نمایه مجلات: | IF: 2.706 Indexed in: ISI, Scopus, PubMed/PMC |
کلیدواژه ها (انگلیسی): | Enterobacterales, healthy people, fecal carriage, ESBL, AmpC, antibiotic resistance |
موضوعات : | QW میکروب شناسی و ایمنی شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی |
کد شناسایی : | 16080 |
ارائه شده توسط : | دکتر محسن ارزنلو |
ارائه شده در تاریخ : | 27 شهریور 1401 07:56 |
آخرین تغییر : | 29 دی 1401 10:20 |
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