سعید, مژگان ، یزدانپوز, زهرا ، خادمی, فرزاد ، واعظ, حمید (1401) شیوع ژنهای بتالاکتاماز وسیع الطیف blaCTXM ،blaSHV و blaTEM در سویههای اشریشیا کلی جدا شده از نمونههای بالینی بیماران مبتلا به عفونت ادراری. International Journal of Basic Science in Medicine ــ 7 (2). ص.ص.89-93. شاپا 2476-664X
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آدرس اینترنتی رسمی : https://ijbsm.zbmu.ac.ir/Article/ijbsm-25606
عنوان انگليسی
Prevalence of Extended-Spectrum Beta Lactamase blaCTXM, blaSHV and blaTEM Genes in Escherichia coli Strains Isolated from Clinical Samples of Patients With Urinary Tract Infections
خلاصه انگلیسی
Introduction: Urinary tract infections (UTIs) are the most prevalent infections in patients worldwide. Escherichia coli is considered as the most prevalent etiological agent of UTIs. The prevalence of extended-spectrum beta-lactamase (ESBL)-producing isolates is a health care concern worldwide. The aims of this study was to determine antibiotic resistance profiles and the prevalence of the blaCTXM, blaSHV, and blaTEM genes in E. coli isolated from clinical samples obtained from patients with UTIs. Methods: From September 2019 to March 2021, a total of 1200 urine samples were collected and analyzed from patients suspected of having UTI referred to Amir-Al-Momenin hospital of Zabol, Sistan and Baluchistan province, south-east of Iran. Antibiotic resistance patterns and the prevalence of the blaCTXM, blaSHV and blaTEM genes were determined using the disk diffusion method and PCR, respectively. Results: The isolates were mostly resistance against ampicillin and trimethoprim-sulfamethoxazole, with 66% and 54% of all isolates being resistant. Also, the isolates investigated were highly susceptible against meropenem and gentamycin (95%). The prevalence of the blaCTX, blaSHV, and blaTEM genes was 22%, 30%, and 24%, respectively. Conclusion: Resistance against ampicillin and trimethoprim-sulfamethoxazole was high, therefore their prescription must be restricted. In addition, the expressions of the blaCTXM, blaSHV, and blaTEM genes were alarmingly high. In order to control the spread of infections by these isolates, constant monitoring of antibiotic resistance patterns is necessary.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | مژگان سعید |
نویسنده : | زهرا یزدانپوز |
نویسنده : | فرزاد خادمی |
نویسنده مسئول : | حمید واعظ |
ضریب تاثیر و نمایه مجلات: | Indexed in: DOAJ , Google Scholar, SID, Magiran |
کلیدواژه ها (انگلیسی): | E. coli, Extended-spectrum beta-lactamase, Urinary tract infection, Antibiotic resistance |
موضوعات : | QW میکروب شناسی و ایمنی شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی |
کد شناسایی : | 16101 |
ارائه شده توسط : | دکتر فرزاد خادمی |
ارائه شده در تاریخ : | 04 مهر 1401 10:45 |
آخرین تغییر : | 04 مهر 1401 10:45 |
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