عسگرزاده, علی ، فولادی, نسرین ، اصغری آذر, وحید ، فولادی سرابی, شهناز ، افزون خیاوی, حمید ، محمودی, مهسا ، صفرزاده, الهام (1401) فاکتور نوروتروفیک مشتق از سرم مغز (BDNF) در بیماران کووید-19 و ارتباط آن با تظاهرات COVID-19. Journal of Molecular Neuroscience ــ 72 (9). ص.ص.1820-1830. شاپا 0895-8696
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آدرس اینترنتی رسمی : https://link.springer.com/article/10.1007/s12031-0...
عنوان انگليسی
Serum Brain-Derived Neurotrophic Factor (BDNF) in COVID-19 Patients and its Association with the COVID-19 Manifestations
خلاصه انگلیسی
COVID-19 is a systematic disease that frequently implies neurological and non-neurological manifestations, predominantly by inducing hypoxia. Brain-derived neurotrophic factor (BDNF) is a key factor in regulating functions of nervous and respiratory systems and has been strongly related to hypoxia. Therefore, this study planned to investigate BDNF association with the COVID-19 manifestations especially neurological impairments and the infection-induced hypoxia. We enrolled sixty-four COVID-19 patients and twenty-four healthy individuals in this study. Patients were divided into two groups, with and without neurological manifestations, and their serum BDNF levels were measured by enzyme-linked immunosorbent assay (ELISA). COVID-19 patients had significantly lower BDNF levels than healthy individuals (p = 0.023). BDNF levels were significantly lower in patients with neurological manifestations compared to healthy individuals (p = 0.010). However, we did not observe a statistically significant difference in BDNF levels between patients with and without neurological manifestations (p = 0.175). BDNF's levels were significantly lower in patients with CNS manifestations (p = 0.039) and higher in patients with fever (p = 0.03) and dyspnea (p = 0.006). Secondly, BDNF levels have a significant negative association with oxygen therapy requirement (p = 0.015). These results strongly suggest the critical association between dysregulated BDNF and hypoxia in promoting COVID-19 manifestations, particularly neurological impairments.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | علی عسگرزاده |
نویسنده : | نسرین فولادی |
نویسنده : | وحید اصغری آذر |
نویسنده : | شهناز فولادی سرابی |
نویسنده : | حمید افزون خیاوی |
نویسنده : | مهسا محمودی |
نویسنده مسئول : | الهام صفرزاده |
ضریب تاثیر و نمایه مجلات: | IF: 3.1 Indexed in: ISI, PubMed/Medline, Scopus, Embase |
کلیدواژه ها (انگلیسی): | BDNF; COVID-19; Dyspnea; Hypoxia; Neurological manifestations. |
موضوعات : | QW میکروب شناسی و ایمنی شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش ايمنولوژی |
کد شناسایی : | 16409 |
ارائه شده توسط : | دکتر الهام صفرزاده |
ارائه شده در تاریخ : | 24 تیر 1402 10:03 |
آخرین تغییر : | 24 تیر 1402 10:03 |
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