پلی مورفیسم(موقییت 509 C/T -) ژن TGF-B در بیماران سقط مکرر خود بخود

عنوان انگليسی

TGF-B1 gene polymorphism (position -509 C/T) in repeated spontaneous abortion (RSA)

خلاصه انگلیسی

Repeated spontaneous abortion is regarded as a common pregnancy complication in southern Iran. The exact cause of RSA has not yet been known. Increases in serum level of autoantibodies, serum lipid levels and change in serum level of proinflammatory cytokines have been reported in RSA cases. TGF-b1 is produced by TH2 lymphocytes and plays an important role in the physiology of pregnancy. Elevated serum level of this cytokine in RSA has already been reported. In this investigation, the change at position /509 of TGF-b1 was studied in 114 RSA and 74 normal female subjects from southern Iran by PCR-RFLP. Results indicate that 45 (39.1%) of RSA and 18 (24.3%) of normal subjects were homozygote CC at this position. In addition 47 (40.9%) of cases and 45 (60.8%) of normal individuals were heterozygote CT. 23 (20%) of 114 and 11 (14.9%) of 74 normal individuals were homozygote TT. The results indicate that there is a statistically significant difference between heterozygote RSA cases and those of normal female individuals. The importance of higher frequency of hetrozygocity among normal subjects in comparison with RSA will be discussed.

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