پلی مورفیسم ژنTGF-B1 (موقعییت G/A -800) در بیماران سقط مکرر خود به خود

امانی, داور and ذوالقدری, ژاله and صمصامی دهقان, عالم تاج and قادری, عباس (1382) پلی مورفیسم ژنTGF-B1 (موقعییت G/A -800) در بیماران سقط مکرر خود به خود. در: کنگره Hippokaration, 4-6 ژوئن 2003, یونان- رودز.

Text - Published Version


gene polymorphism (position -800 G/A) in repeated spontaneous abortion (RSA

English Abstract

TGF-b1 is a multifunctional TH2 cytokine with potential biological function for regulation of cell growth and differentiation. Several polymorphisms in TGF-b1 gene have been reported some with important correlation with disease severity. Elevated serum level of TGF-b1 in repeated spontaneous abortion has already been reported. In this investigation the change at position -/800 (G/A) of TGF-b1 gene was studied using PCR-RFLP in 114 cases of RSA and 80 normal Iranian female subjects. Results indicated that 87 (76.3%) out of 114 cases and 60 (75%) out of 80 normal subjects were homozygote GG at this position. In addition 26 cases (22.8%) and 20 (25%) of normal subject were heterozygote AG. Only one of the patients appeared to be homozygote AA. None of the normal individuals was found to be homozygote AA at this position. The results of this investigation indicate that there are no statistical significant differences between the repeated spontaneous abortion cases and the control subjects in respect to the polymorphism at position -/800 of TGF-b1 gene.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :داور امانی
Uncontrolled Keywords:سقط مکرر خود بخود، پلی مورفیسم ژن سایتوکاین، TGF-B1
کلیدواژه ها (انگلیسی):Recurrent spontaneous abortion; TGF-B1; Cytokine gene polymorphism
Subjects:WQ Obstetrics
QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
ID Code:1655
Deposited By: Dr Davar Amani
Deposited On:01 Jul 1389 04:25
Last Modified:07 Jul 1393 05:14

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