تاثیر رژیم متفاوت آماده سازی اندومتر در سیکل انتقال جنین فریز روی پیامدهای بارداری حاملگی های تک قلو در بیماران با سندرم تخمدان پلی کیستیک : یک کارآزمایی تصادفی کنترل شده

عنوان انگليسی

The Influence Of Different Endometrium Preparation Regimen For Frozen Thawed Embryo Transfer On Perinatal Outcomes Of Singletons Pregnancy In Patients With Polycystic Ovary Syndrome: A Randomized Controlled Trial

خلاصه انگلیسی

Introduction: According to the lack of strong evidence, whether the different frozen thawed embryo transfer (FET) protocols in patients with polycystic ovarian syndrome (PCOS) have any effect on its success is still unclear. This study was performed to compare the effect of hormone replacement treatment (HRT) protocols and gonadotropin-releasing hormone GnRH agonist (GnRHa)-HRT protocols on perinatal outcomes of singletons pregnancy in patients with PCOS. Material and Methods: The study design was a randomized controlled trial (RCT) conducted at a tertiary referral hospital. A total of 132 patients with PCOS undergoing FET cycles were included in this study. The patients were randomly divided into two groups according to a computer-generated method. The GnRHa-HRT group (n = 66) had pituitary suppression before steroid hormone administration whereas HRT group (n = 66) commenced steroid supplementation without prior pituitary desensitization. Primary outcome was considered birthweight of singleton newborns. Results: There were no differences in birth weight of newborns between two groups (p=0.50). No significant differences were found between two groups for preeclampsia, gestational diabetes mellitus, IUGR, first trimester bleeding, and preterm labour. Moreover, neonatal anomalies were not significantly different between two groups, but no neonatal anomalies were reported from group HRT. Conclusion: The findings indicated that neonatal birth weight and other prenatal outcome were not significantly different between two groups. It seems that the use of GnRH agonist creates additional burdens and adverse events for the patient, and the use of estradiol alone is an effective, less complicated and economically cost-effective protocol for patients with PCOS.

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