title

مقاومت آنتی بیوتیکی، حاملی اینتگرون و ژنهای مقاومت به فلوروکینولونها در ایزولهای اسنیتوباکتر بومانی

عاشوری, پرستو and محمدشاهی, جعفر and نیک بین, وجیهه السادات and پیری دوگاهه, هادی and محمدی قلعه بین, بهنام and رفاهی, سهیلا and تیمورپور, امیر and اسمعیلی زاد, مجید and میرزانژاد اصل, حافظ and تیمورپور, رقیه (1401) مقاومت آنتی بیوتیکی، حاملی اینتگرون و ژنهای مقاومت به فلوروکینولونها در ایزولهای اسنیتوباکتر بومانی. Archives of Clinical Infectious Diseases ــ 17 (5). e120590. شاپا 2345-2641

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Title

Antimicrobial Resistance, Integron Carriage, and Fluoroquinolone Resistance Genes in Acinetobacte baumannii Isolates

English Abstract

Background: Acinetobacte is the leading cause of pneumonia and sepsis in the ICU ward. Accordingly, in the present study, the antibiotic susceptibility pattern, presence, and dissemination of different classes of integrons and fluoroquinolone resistance genes were investigated among A. baumannii isolates. Methods: In this descriptive, cross-sectional study, during a period of 24 months (2018 - 2020), 100 isolates of A. baumannii were isolated from different clinical specimens of patients admitted to the two teaching hospital in Ardabil province in the northwest of Iran. Kirby -Bauer disk diffusion, PCR, and sequencing methods were used for antimicrobial susceptibility testing and gene and mutation verification. Results: The resistance rates to all tested antibiotics were found to be between 78% and 100%. No isolate was resistant to polymyxin B. Multidrug-resistant (MDR) rate among tested clinical isolates was about 99%. The prevalence of class 1, 2, and 3 integrons was found to be 70%, 21%, and 0%, respectively. The aadA1 cassette gene was detected in all class 1 integron-carrying strains. Conclusions: High-level antibiotic resistance and a high prevalence of integrons were observed among these clinical isolates. Our findings highlighted the need for continuous monitoring of resistant isolates.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :پرستو عاشوری
نویسنده مسئول :جعفر محمدشاهی
نویسنده :وجیهه السادات نیک بین
نویسنده :هادی پیری دوگاهه
نویسنده :بهنام محمدی قلعه بین
نویسنده :سهیلا رفاهی
نویسنده :امیر تیمورپور
نویسنده :مجید اسمعیلی زاد
نویسنده :حافظ میرزانژاد اصل
نویسنده مسئول :رقیه تیمورپور
Additional Information:Indexed in: Scopus, ESCI
Uncontrolled Keywords:اسنیتوباکتر بومانی، ICU، پنومونی، عفونت ادراری، اینتگرون
کلیدواژه ها (انگلیسی):Acinetobacte baumannii, ICU, Pneumonia, Urinary Tract Infection, Integron
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:16760
Deposited By: Dr Roghayeh Teimourpour
Deposited On:27 Nov 1401 08:52
Last Modified:23 Sep 1402 11:11

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