پروفایل ادراری هیدروکربن های آروماتیک چندهسته ای و ترکیبات مرتبط با آنها در زنان شاغل در سالن های زیبایی

عنوان انگليسی

Urinary profile of PAHs and related compounds in women working in beauty salons

خلاصه انگلیسی

Polycyclic aromatic hydrocarbons (PAHs) are a group of chemical compounds which interest to human biological monitoring researches because of their potential carcinogenic, mutagenic, and teratogenic properties. However, the exposure of female beauticians to these contaminants is not well-reported. For biomonitoring of potential exposure of female cosmeticians to PAHs in beauty salons, urine samples were taken from cosmetologist women (n = 50.00) and housewives (n = 35.00) as the exposure group (EG) and control group (CG), respectively. Next, unmetabolized PAHs levels as well as the concentration of - 1-hydroxypyrene (1-OHP) were analyzed in these specimens. In addition, since benzene has some common source with PAHs, in this study t, t’-Muconic acid (TTMA) level was also determined as the metabolite and indicator of exposure to benzene. The results indicated a high detection frequency of the target compounds (PAHs, 1-OHP and TTMA) in the urine specimens of beauticians. The results also showed that there is a significant difference between the concentration of these pollutants in the urine specimens of the exposure and control groups. The median concentration of ΣPAHs, 1-OHP, and TTMA in the before exposure (BE) specimens collected from the exposure group were 337.42 ng/L, 593.92 ng/L, and 247.90 μg/L, respectively. However, a higher concentration of these contaminants was observed in the after exposure specimens with a median concentration of 423.29 ng/L, 745.03 ng/L, and 310.97 μg/L, respectively. In terms of contribution of PAHs compounds in total toxic equivalents, DahA, BaP, and IndP with 59.03, 28.73, and 2.86 % had the largest share. In this study, it was also observed that some kidney damage biomarkers as well as some oxidative stress injury biomarkers are positively and significantly correlated with the urinary values of ∑PAHs. Thus, it can be concluded that high health risks threaten the female beauticians regarding kidney injury and DNA oxidative stress.

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