سطح اینترلوکین 6 و محدودیت جریان هوا در بیماران جانباز شیمیائی ریوی با بیماری انسدادی مزمن ریه

عطاران, داود and محمدزاده لاری, شهرزاد and توحیدی, محمد and قبادی مراللو, حسن and آیت اللهی, حسین and خواجه دلوئی, محمد and قانعی, مصطفی and بصیری, رضا (1389) سطح اینترلوکین 6 و محدودیت جریان هوا در بیماران جانباز شیمیائی ریوی با بیماری انسدادی مزمن ریه. International Journal of Chronic Obstructive Pulmonary Disease ــ 5 . pp. 335-340. شاپا ISSN:1178-2005

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Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease

English Abstract

Objectives: Chronic obstructive pulmonary disease (COPD) is one of the main late complications of sulfur mustard poisoning. The aim of this study was to evaluate serum levels of interleukin (IL)-6 in war veterans with pulmonary complications of sulfur mustard poisoning and their correlation with severity of airways disease. Methods: Fifty consecutive patients with sulfur mustard poisoning and stable COPD, and of mean age 46.3 ± 9.18 years were enrolled in this study. Thirty healthy men were selected as controls and matched to cases by age and body mass index. Spirometry, arterial blood gas, six-minute walk test, BODE (body mass index, obstruction, dyspnea, and exercise capacity), and St George’s Respiratory Questionnaire about quality of life were evaluated. Serum IL-6 was measured in both patient and control groups. Results: Fifty-four percent of patients had moderate COPD. Mean serum IL-6 levels were 15.01 ± standard deviation (SD) 0.61 pg/dL and 4.59 ± 3.40 pg/dL in the case and control groups, respectively (P = 0.03). There was a significant correlation between IL-6 levels and Global Initiative for Chronic Obstructive Lung Disease stage (r = 0.25, P = 0.04) and between IL-6 and BODE index (r = 0.38, P = 0.01). There was also a significant negative correlation between serum IL-6 and forced expiratory volume in one second (FEV1, r = −0.36, P = 0.016). Conclusion: Our findings suggest that serum IL-6 is increased in patients with sulfur mustard poisoning and COPD, and may have a direct association with airflow limitation.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :داود عطاران
نویسنده مسئول :شهرزاد محمدزاده لاری
نویسنده :محمد توحیدی
نویسنده :حسن قبادی مراللو
Additional Information:Indexed in: PubMed/PMC , EMBASE, Scopus ,Chemical Abstracts Service' (CAS)
Uncontrolled Keywords:سولفور موستارد, اینترلوکین 6,بیماری انسدادی مزمن ریه, التهاب, سلاح شیمیائی.
کلیدواژه ها (انگلیسی):sulfur mustard, chronic obstructive pulmonary disease, interleukin-6, inflammation, chemical warfare
Subjects:WF Respiratory System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:1727
Deposited By: Dr Hassan Ghobadi
Deposited On:26 Jul 1389 06:12
Last Modified:11 Apr 1399 11:58

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  • سطح اینترلوکین 6 و محدودیت جریان هوا در بیماران جانباز شیمیائی ریوی با بیماری انسدادی مزمن ریه. (deposited 26 Jul 1389 06:12) [Currently Displayed]

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