عوارض قلبی و کبدی فلوکستین در موش های صحرایی نر و ماده نوجوان

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عنوان انگليسی

Cardiac and hepatic side effects of fluoxetine in male and female adolescent rats

خلاصه انگلیسی

Background: Fluoxetine (FLX) is a widely used drug for some psychiatric disorders. This antidepressant drug selectively inhibits the presynaptic reuptake of serotonin. Adverse effects of FLX on several organs of the body such as the hepatic and cardiac systems have been reported during treatment. Therefore, the present study aimed to investigate the side effects of FLX treatment during adolescence on the cardiac and hepatic systems. Methods: We administrated the FLX (5mg/kg/day, gavage) on postnatal days 21-60 for male and female rats. Following treatment duration, the blood samples were collected to measure the hepatic enzymes. In addition, the liver and heart of animals were subjected to histopathological assessment. Results: Fluoxetine significantly raised serum alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) in males, whereas the aspartate aminotransferase (AST) level increased in male and female animals. In the histopathological study, hepatic plates were more seriously affected and the sinusoids were irregular in adolescent male rats. Degenerative changes were observed especially in the 1st and 2nd zones of FLX-treated male rats. Signs of inflammation and accumulation of lymphoid groups were frequently observed in the portal triad of the hepatic lobule. These conditions were more severe in male livers. Minimum or nearly normal changes were observed in female liver slides. In addition, the histological assessment indicated that treatment with FLX during adolescence also increased the weight of the heart as well as the wall thickness of the right and left ventricles (hypertrophy) in male and especially female animals. Conclusion: The increasing usage of FLX during adolescence highlights the considerations of the side effects of this drug.

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• عوارض قلبی و کبدی فلوکستین در موش های صحرایی نر و ماده نوجوان. (deposited 19 آذر 1402 09:03) [Currently Displayed]

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