فرید مجتهدی, مریم ، معینی, اشرف ، کاشانی, لادن ، میرزارحیمی, تیبا (1402) تاثیر لتروزول به عنوان یک مکمل در پروتکل آنتاگونیست GnRH بر پیامدهای IVF/ICSI در زنان مبتلا به اندومتریوز: یک کارآزمایی بالینی تصادفی شده. Middle East Fertility Society Journal ــ 28 (1). شاپا 1110-5690
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آدرس اینترنتی رسمی : https://mefj.springeropen.com/articles/10.1186/s43...
عنوان انگليسی
The effect of letrozole as an adjunct in GnRH-antagonist protocol on IVF/ICSI outcome in women with endometriosis: a randomized clinical trial
خلاصه انگلیسی
Background: To evaluate the effect of adding letrozole to the antagonist ovarian stimulation protocol (COS) on in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcome in endometriosis patients. Methods: This randomized clinical trial was carried out in the department of infertility treatment at Arash Women’s Hospital from May 2019 to May 2021. The eligible women with normal ovarian reserve tests who had endometriosis diagnosis and underwent IVF/ICSI cycles were evaluated. A flexible regimen of GnRH-antagonist protocol was used for COS. In the experimental (n = 34), the patients received 5 mg letrozole daily for the first 5 days in combination with 150 IU of recombinant follicle-stimulating hormone (rFSH). In the control group (n = 30), the patients received only the same dose of rFSH. The treatment cycle was compared between groups. Results: Analysis of demographic characteristics, severity of endometriosis, and baseline hormonal tests of patients showed that the two groups were similar and comparable. The means of total used gonadotropins ampoules and serum E2 level on oocyte trigger day in the letrozole group were significantly lower than those of in the control group (P = 0.03 and P = 0.004, respectively). No statistically significant difference in terms of the total number of retrieved and MII oocytes as well as the total numbers of obtained and top-quality embryos, and cryopreserved embryos was found. Conclusion: The co-treatment of letrozole with gonadotropins during the antagonist protocol was associated with a reduction in the total dose of gonadotropins, although it had no effect on the oocyte or embryo yield in patients with endometriosis. Trial registration: The study was registered in the Iranian Registry of Clinical Trials on 2018 -07-13
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | مریم فرید مجتهدی |
نویسنده مسئول : | اشرف معینی |
نویسنده : | لادن کاشانی |
نویسنده : | تیبا میرزارحیمی |
ضریب تاثیر و نمایه مجلات: | Indexed in: Scopus, ESCI, Embase |
کلیدواژه ها (انگلیسی): | An aromatase inhibitor; In vitro fertilization; Letrozole; Live birth; Oocyte maturity |
موضوعات : | WQ مامایی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه بیهوشی، زنان و زایمان |
کد شناسایی : | 17747 |
ارائه شده توسط : | خانم صغری گلمغانی |
ارائه شده در تاریخ : | 19 آذر 1402 08:53 |
آخرین تغییر : | 01 بهمن 1402 11:17 |
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