تاثیر شیاف بنفشه معطر بر آتروفی واژن یائسگی: یک کارآزمایی بالینی سه سو کور

عنوان انگليسی

Effect of Viola odorata vaginal suppository on menopausal vaginal atrophy: A Triple-blind randomized clinical trial

خلاصه انگلیسی

Background Vaginal atrophy is an often neglected symptom of menopause, which affected about 90% of women. Women tend to use alternative medicine such as herbs rather than estrogen replacement therapy to alleviate it. Viola odorata contains flavonoids in the form of phytoestrogens and probably can be effective in treatment of vaginal atrophy. This study was conducted to investigate the effect of Viola odorata vaginal suppository on menopausal vaginal atrophy. Methods This approved triple-blind randomized clinical trial, 8-weeks, study was conducted on 60 postmenopausal women from September 2022 until January 2023. Eligible participants were divided randomly into two groups of treatment (Viola odorata suppository) and placebo (glycerin suppository) after obtaining informed consent. Data of the socio-demographic questionnaire, vaginal pH, and vaginal maturation index (VMI) were collected before and at the end of the study. Subjective symptoms of vaginal atrophy (dryness, irritation, itching, and dyspareunia) were assessed before, 4th, and 8th weeks of intervention period by self-assessments. Data were analyzed using Independent t-test, Chi-square, Mann Whitney U, and Wilcoxon test by SPSS ver 23. Results There were no significant differences between the two groups at the beginning of the study in vaginal atrophy symptoms, vaginal pH, and VMI. Subjective symptoms of vaginal atrophy (p<0.001), vaginal pH (p<0.001), and VMI (p<0.001) were improved in the Viola odorata group 8 weeks of treatment. Conclusion Viola odorata vaginal suppository reduced the menopausal vaginal atrophy symptoms. Considering Viola odorata is a natural product with low cost, it can use in menopausal vaginal atrophy treatment.

Document Downloads