شیوع سویه های اشریشیا کلی مقاوم به کارباپنم تولید کننده متالو بتا لاکتاماز جدا شده از عفونت های دستگاه ادراری

عنوان انگليسی

Prevalence of carbapenem-resistant Metallo-Beta-Lactamase-producing Escherichia coli strains isolated from urinary tract infections

خلاصه انگلیسی

Background: Urinary tract infection (UTI) is one of the most prevalent bacterial diseases worldwide. Escherichia coli is a well-known etiological agent of UTI. The emergence and spread of metallo-beta-lactamase (MBL)-producing E. coli is a serious threat to public health. This study aimed to investigate the antibiotic resistance pattern and prevalence of MBL-producing E. coli isolated from UTI. Methods: From January 2020 to June 2021, 1200 urine specimens were collected from patients suspected of having UTI. Antibiotic susceptibility testing was carried out by the disk diffusion method. The prevalence of MBL (blaVIM, blaIMP, blaSPM, and blaNDM) genes was determined by the polymerase chain reaction (PCR) method. Results: The highest susceptibility was observed against amikacin (96%) and gentamicin (95%). The isolates were mostly resistant against ampicillin (72%) and cephalothin (60%). All carbapenem-resistant isolates were MBL-positive. Based on the results of PCR, 75% of the isolates were blaNDM-positive. Conclusion: Resistance to some antibiotics, such as ampicillin and cephalothin, was high, and their prescription must be restricted. The prevalence of MBL-producing isolates was not high; however, due to the high level of resistance against other antibiotics, continuous monitoring of MBL-producing isolates is highly essential.

Document Downloads