فرزانه, اسماعیل and مصطفی زاده, بابک and نسل سراجی, فرناز and صیاد رضایی, ایرج (1389) اثرات دوز پائین نالوکسان در بروز تشنج در درمان مسمومیت با ترامادول. در: کنگره بین المللی بررسی اثرات زنوبیوتیک ها, September 4 - 8, 2010, ترکیه-استامبول.
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Title
Seizurogenic Effects of Low-dose Naloxone in Tramadol Overdose
English Abstract
Objective: Tramadol is used in treatment of moderate to severe pain. Nowadays tramadol overdose is one of the common emergencies. Naloxone is an antagonist which is used as a first step of treatment in these patients. This study was designed to evaluate the seizurogenic effects of naloxone in tramadol overdose. Methods: 124 patients with the diagnosis of tramadol overdose were divided to receive low-doses of intravenous naloxone (0.8 mg, case group) or just supportive cares (control group). All patients in case and control groups were observed by a single emergency resident and fallowed for 1.5 hours to document the happening of seizures. Results: In the naloxone group, incidence of seizure was higher than in control group. The possibility of seizure occurrence was significantly higher in naloxone group than the control group (P < 0.05). Conclusion: Naloxone induced a seizurogenic effect in patients with tramadol overdose. This finding could be considered in the management of patients with tramadol overdose.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| زبان سند : | انگلیسی |
| نویسنده مسئول : | اسماعیل فرزانه |
| Uncontrolled Keywords: | بیش مصرفی ترامادول - نالوکسان - تشنج |
| کلیدواژه ها (انگلیسی): | Tramadol overdoses , Naloxone ; Seizure |
| Subjects: | QV pharmacology WL Nervous system |
| Divisions: | Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious |
| ID Code: | 1820 |
| Deposited By: | Dr Esmaeil Farzaneh |
| Deposited On: | 08 Sep 1389 01:10 |
| Last Modified: | 01 Dec 1391 14:09 |
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