ارتباط سطح مت هموگلوبین با پروگنوز بیماران در مسمومیت با قرص برنج

Title

Association of blood level of methemoglobin with clinical outcome of patients with aluminium phosphide poisoning

English Abstract

Background: Although methemoglobinemia following aluminum phosphide (AlP) intoxication has been reported, probable effect of blood level of methemoglobin (Met-Hb) on outcome of AlP intoxicated patients has not yet been investigated. This study aimed to evaluate this probable association. Methods: This prospective study was carried out at Loghman-Hakim poison hospital from April 2009 to August 2009 All patients aged >12 years who had ingested AlP and were admitted at the hospital were enrolled into the study. Using the co-oximetry, Met-Hb was measured at the time of admission and was repeated 24 hours later if the patient survived. Results: 48 AlP intoxicated cases including 24 males were enrolled into the study. Mean age of the patients was 25.5± 9.5 years. There was significant association between Met-Hb blood level which measured at the time of admission and mortality (2.4%± 7.1% in survivors versus 15.2%± 13.5% in non-survivors, P<0.001). The same association was found at the 2nd day of admission (2.9%±8.2% in survivors versus 26.5%±19.9% in non-survivors, P=0.02). Conclusions: The present study found an association between blood level of Met-Hb and mortality in AlP intoxicated cases. Whether prophylactic administration of vitamin C and methylene blue can improve outcome of AlP-intoxicated cases should be investigated in future investigations.

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