شیوع ضایعات پیش سرطانی در اردبیل, استانی با شیوع بالای آدنوکارسینوم معده

ملک زاده, رضا and ستوده, مسعود and درخشان, محمدحسین and یزدانبد, عباس and میکاییلی, جواد and مرآت, شاهین and یونسی, علی and توانگر, سید محمد and عابدی اردکانی, بهنوش and ستوده منش, رسول and پورشمس, اکرم and اصغری, علی عسگر and دولتشاهی, شهاب and علیزاده, زیاد and عرشی, شهنام and مجیدپور, علی and میرمومن, شهرام and فلشر, دیوید (1382) شیوع ضایعات پیش سرطانی در اردبیل, استانی با شیوع بالای آدنوکارسینوم معده. Journal of Clinical Pathology ــ 57 (1). pp. 37-42. شاپا 0021-9746

Text - Published Version

Official URL: http://jcp.bmj.com/


Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the northwest of Iran

English Abstract

BACKGROUND/AIMS: Ardabil Province, in northwestern Iran, has the highest rate of gastric (predominantly cardia) adenocarcinoma in Iran. This study aimed to investigate the feasibility of endoscopic screening and to look for associated Helicobacter pylori infection and gastric precancerous lesions. METHODS: One thousand one hundred and five adult volunteers, residents of Ardabil and Meshkinshahr, districts, 40 years old and above were selected and invited by a simple random household canvass in rural and urban locations. Informed consents were obtained and upper gastrointestinal video endoscopy was performed to biopsy all visible lesions and standard sites in the antrum, corpus, and cardia. RESULTS: One thousand and eleven of the invited individuals agreed to participate, including 494 men and 517 women, with a mean (SD) age of 53.32 (10.39) years. Endoscopy was well tolerated by all subjects; 96.7% of antral and 80.7% of cardia mucosal biopsies were satisfactory. The urease test or histology for H pylori was positive in at least 89.2% of subjects. Histological evidence of mucosal atrophy was seen in 39.3% of antral and 21.9% of cardia samples. Chronic gastritis with or without activity, reactive atypia of glandular epithelium, intestinal metaplasia, dysplasia, and cancer were found in 95.1%, 38.0%, 8.7%, 0.2%, and 0.3% of antral and 85.3%, 22.9%, 3.8%, 0.3%, and 0.1% of cardiac biopsies, respectively. CONCLUSION: Endoscopic screening for upper gastrointestinal diseases was feasible and well tolerated in Ardabil, Iran. Most subjects showed H pylori infection. Atrophic gastritis, reactive atypia, and intestinal metaplasia were common in antrum, corpus, and cardia subsites

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :رضا ملک زاده
نویسنده :عباس یزدانبد
Additional Information:Index Medicus (Medline), ISI Current Contents (Web of Science), Excerpta Medica (Embase)
کلیدواژه ها (انگلیسی):gastric cancer, precancerous lesions, Ardabil, Iran
Subjects:WI Digestive System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:1858
Deposited By: Dr Abbas Yazdanbod
Deposited On:23 Sep 1389 05:03
Last Modified:24 Nov 1391 12:38

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