اثرات مفید نالوکسان در درمان مسمومیت با بنزودیازپین ها:یافته های یک مطالعه مقدماتی

Title

Benefit Effect of Naloxone in Benzodiazepines Intoxication: Findings of a Preliminary Study

English Abstract

Background: Naloxone, as a low-priced and available drug, may be useful in improvement of signs and symptoms of benzodiazepines intoxication. The aim of this study was assessment of its effect on benzodiazepines poisoning. Methods: In this clinical trial study, patients with typical signs and symptoms of benzodiazepines poisoning who referred to a poisoning center in Tehran in 2008 were selected. After recording of patient characteristics, supportive treatment initiated and patients randomly assigned to IV injection of two 0.4 mg naloxone ampules group (case) or control group. Their signs and symptoms were evaluated 0.5 hour later again. Each of diazepam, clonazepam and alperazolam drug group had 30 patients and lorazepam drug group had 26 patients which half of the patients in each drug group received naloxone. Results: Most of participants were female and the mean age was 28 yr. There were no significant differences between case and control groups in age, sex, time of drug consumption, tablet counts, sings and symptoms and level of consciousness in admission time in each drug types. After naloxone injection in case groups, all signs and symptoms significantly improved in all drug tyeps in comparison to control groups except nystagmus. In addition, level of consciousness significantly improved in case groups in all drug types except lorazepam. Conclusion: Findings of the study showed that naloxone is effective in management of benzodiazepines poisoning. However, future clinical trials with greater sample size are recommened.

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