اثر کاپتوپریل بر TNF-a و IL-10 در کبد رت های BDL شده

امیرشاهرخی, کیوان and قاضی خوانساری, محمود and محمدی فرانی, احمد and کریمیان, گلنار (1389) اثر کاپتوپریل بر TNF-a و IL-10 در کبد رت های BDL شده. Iranian Journal of Immunology ــ 7 (4). pp. 247-251. شاپا 1735-1383

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Official URL: http://iji.sums.ac.ir/december_2010.html


Effect of Captopril on TNF-α and IL-10 in the Livers of Bile Duct Ligated Rats.

English Abstract

Background: The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensin-converting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats. Objective: The present study was conducted to investigate the effects of captopril on cytokine production in hepatic fibrosis induced by a bile duct ligation model in rats. Methods: Male rats were divided into four groups including; control, sham operated, BDL, and BDL plus captopril (10 mg/kg/day, orally). After 28 days of treatment, the livers were removed for cytokine analysis. Hepatic interleukin (IL)-10 and tumor necrosis factor (TNF)-α levels were measured. Results: Captopril treatment decreased the hepatic content of the proinflammatory cytokine TNF-α and increased the anti-inflammatory cytokine IL-10. Conclusion: the present study suggests that the protective effect of captopril on hepatic fibrosis is likely to be mediated by cytokine production.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
Additional Information:ImpactFactor: indexing: 1-MEDLINE,PUBMED,Web of Science (ISI), 2-EMBASE,SCOPUS,Chemical Abstracts, 3-EMNursing,GEOBASE,Cambridge Scientific Abstracts,Global Health,Index Medicus for Eastern Mediterranean Region (IMEMR),
کلیدواژه ها (انگلیسی):Captopril, Hepatic fibrosis, IL-10, TNF-α
Subjects:QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:1914
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:14 Oct 1389 00:10
Last Modified:07 Jul 1393 06:09

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