اثر کاپتوپریل بر TNF-a و IL-10 در کبد رت های BDL شده

امیرشاهرخی, کیوان ، قاضی خوانساری, محمود ، محمدی فرانی, احمد ، کریمیان, گلنار (1389) اثر کاپتوپریل بر TNF-a و IL-10 در کبد رت های BDL شده. Iranian Journal of Immunology ــ 7 (4). ص.ص.247-251. شاپا 1735-1383

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آدرس اینترنتی رسمی : http://iji.sums.ac.ir/december_2010.html

عنوان انگليسي

Effect of Captopril on TNF-α and IL-10 in the Livers of Bile Duct Ligated Rats.

خلاصه انگلیسی

Background: The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensin-converting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats. Objective: The present study was conducted to investigate the effects of captopril on cytokine production in hepatic fibrosis induced by a bile duct ligation model in rats. Methods: Male rats were divided into four groups including; control, sham operated, BDL, and BDL plus captopril (10 mg/kg/day, orally). After 28 days of treatment, the livers were removed for cytokine analysis. Hepatic interleukin (IL)-10 and tumor necrosis factor (TNF)-α levels were measured. Results: Captopril treatment decreased the hepatic content of the proinflammatory cytokine TNF-α and increased the anti-inflammatory cytokine IL-10. Conclusion: the present study suggests that the protective effect of captopril on hepatic fibrosis is likely to be mediated by cytokine production.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
اطلاعات اضافی :ImpactFactor: indexing: 1-MEDLINE,PUBMED,Web of Science (ISI), 2-EMBASE,SCOPUS,Chemical Abstracts, 3-EMNursing,GEOBASE,Cambridge Scientific Abstracts,Global Health,Index Medicus for Eastern Mediterranean Region (IMEMR),
کلید واژه ها (انگلیسی):Captopril, Hepatic fibrosis, IL-10, TNF-α
موضوعات :QV فارماکولوژی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فارماکولوژی
کد شناسایی :1914
ارائه شده توسط : دکتر کیوان امیرشاهرخی
ارائه شده در تاریخ :14 دی 1389 00:10
آخرین تغییر :07 مهر 1393 06:09

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