اثر آلوئه ورا / کرم روغن زیتون در مقایسه با کرم بتامتازون در ضایعات مزمن پوست پس از مواجهه با گاز خردل: یک کارآزمایی بالینی تصادفی دو سو کور.

پناهی, یونس and داوودی, سید مسعود and صاحبکار, امیر حسین and بیرق دار, فاطمه and دادجو, یحیا and فیضی, ایرج and امیرچوپانی, گلنوش and زمانی, علی (1391) اثر آلوئه ورا / کرم روغن زیتون در مقایسه با کرم بتامتازون در ضایعات مزمن پوست پس از مواجهه با گاز خردل: یک کارآزمایی بالینی تصادفی دو سو کور. Cutaneous and ocular toxicology ــ 31 (2). pp. 95-103. شاپا 1556-9527

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Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial

English Abstract

BACKGROUND: Chronic pruritic skin lesions are among the common late complications of sulfur mustard intoxication. In the present randomized double-blind clinical trial, therapeutic efficacy of Aloe vera/olive oil combination cream in the alleviation of these lesions was evaluated and compared to that of betamethasone 0.1% cream. METHODS: Sixty-seven Iranian chemical warfare-injured veterans were randomized to apply A. vera/olive oil (n=34, completers=31) or betamethasone 0.1% (n=33, completers=32) cream twice daily for 6 weeks. Evaluation of pruritus severity was performed using a pruritic score questionnaire and visual analogue scale (VAS). RESULTS: Both treatments were associated with significant reductions in the frequency of pruritus (p<0.05), burning sensation (p<0.01 and p<0.001 in A. vera/olive oil and betamethasone group, respectively), scaling (p<0.01 and p<0.05) and dry skin (p<0.001) at the end of trial. Fissure and excoriation were only reduced in the A. vera group (p<0.05). The change in the frequency of hyper- and hypopigmentation lesions, blisters, erythema and lichenification did not reach statistical significance in any of the groups (p>0.05). Mean pruritus (p<0.05) and VAS scores (p<0.01 and p<0.05) were significantly decreased by the end of trial in both groups. The rate of improvement in the pruritus severity [defined as being classified in a less severe category (mild, moderate and severe)] was found to be comparable between the groups (p>0.05). CONCLUSION: A. vera/olive oil cream was at least as effective as betamethasone 0.1% in the treatment of sulfur mustard-induced chronic skin complications and might serve as a promising therapeutic option for the alleviation of symptoms in mustard gas-exposed patients.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :یونس پناهی
نویسنده :سید مسعود داوودی
نویسنده :امیر حسین صاحبکار
نویسنده :فاطمه بیرق دار
نویسنده :یحیا دادجو
نویسنده :ایرج فیضی
نویسنده :گلنوش امیرچوپانی
نویسنده :علی زمانی
Additional Information:2012 Impact Factor: 1.044 Indexed/Abstracted in: PubMed/MedLine, Science Citation Index Expanded , BIOBASE, Biological Abstracts, BIOSIS Previews, Chemical Abstracts, EMBASE, EMBIOLOGY, Environment Complete, Journal Citation Reports/Science Edition, SciSearch, SCOPUS, Toxicology Abstracts CABI Global Health, Abstracts on Hygiene and Communicable Diseases, Agricultural Economics Database, Horticultural Science Abstracts, Horticultural Science Database, Nutrition Abstracts and Reviews Series A, Nutrition and Food Sciences Database, NutritionCD, Plant Protection Database.
کلیدواژه ها (انگلیسی):Aloe vera, olive oil, betamethasone, sulfur mustard, pruritus
Subjects:QV pharmacology
WR Dermatology
Divisions:Faculty of Medicine > Department of Surgery
ID Code:1942
Deposited By: Dr Ali Nemati
Deposited On:06 Feb 1393 12:28
Last Modified:10 Apr 1398 09:57

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