title

نقش آمین اکسیداز در گیاهان و اثرات ضد سرطانی آن

طلایی, سمیه and اسدی, اسداله and امانی, مجتبی (1389) نقش آمین اکسیداز در گیاهان و اثرات ضد سرطانی آن. در: همایش ملی پروتئومیکس, 7- 6 آبان 1389, دانشگاه شیراز.

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Title

Function of amine oxidases in plants and inhibitory effect of them on cancer

English Abstract

Abstract Amine oxidases (AOs) present a class of enzymes, which are divided into two main groups based on chemical nature of the attached cofactor, including the AOs containing flavin adenine dinucleotide, (FAD-AOs, EC 1.4.3.4) and copper-containing amine oxidases, (CuAOs, EC 1.4.3.6), which have a tightly bound copper ion in their molecule. FAD-AOS and CuAOS present in all kinds of organisms such as bacteria, yeasts, mushrooms, various plants, and animals and catalyse the oxidative deamination of mono- and polyamines (essential compounds for cell growth and proliferation). Therefore, amine oxidases and products deriving from amines oxidation are essential in physiological processes. In plants H2O2, deriving from amines oxidation, has been correlated with cell wall maturation and lignifications during development, cell wall strength induction during pathogen infection, cell death induction during hypersensitive response and expression of defence genes. Aldehydes driving from amines oxidation involved in secondary metabolite synthesis and abiotic stress tolerance. Because of the higher content of biogenic amines in tumour cells in comparison to normal cells, AOs could behave as anticancer agent via apoptosis induction by H2O2production.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :سمیه طلایی
نویسنده :اسداله اسدی
نویسنده :مجتبی امانی
کلیدواژه ها (انگلیسی):Flavin adenine dinucleotide containing amine oxidases , copper-containing amine oxidases , development , defence , apoptosis
Subjects:QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biophysics
ID Code:1952
Deposited By: Dr Mojtaba Amani
Deposited On:02 Nov 1389 13:10
Last Modified:18 Oct 1398 09:22

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