نوبخت, ملیحه and آسالگو, سارا and رهبر روشندل, ناهید and موسوی زاده, کاظم and نجف زاده, نوروز (1389) اثرات سیلیبینین روی تمایز سلولهای بنیادی فولیکول مو به سلولهای شبیه نورون. American Journal of Biochemistry and Molecular Biology ــ 1 (2). pp. 212-222. شاپا 2150-4210
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Official URL: http://scialert.net/jindex.php?issn=2150-4210
Title
Effects of Silibinin on Hair Follicle Stem Cells Differentiation to Neural-like Cells
English Abstract
Abstract: The hair follicle stem cells are an abundant and easily accessible source of pluripotent adult stem cells. Hairfollicle stem cells differentiate into neurons and glial cells in vitro and express stem cell markers such as tubulin, RIP, P75, and S100. Silibinin, a flavonolignan and the active component of Milk thistle (Silybum Marianum) has been used as a dietary supplement and herbal medication. The aim of the present study was to investigate the effects of Silibinin on hair follicle stem cells differentiation to neural-like cells. The bulge region of the rat whisker was isolated and cultured in Dulbecco’s modified Eagle’s medium supplemented with different concentrations of silibinin and Neurotrophin-3. One week later , bulge cells immunostained with Nestin and p75 and then with tubulin . The morphological and biological features of cultured bulge cells were observed by light microscopy. Present data demonstrated that silibinin (0.5 μg mL-1) can promote differentiation of hair follicle stem cells to neural-like cells.
Item Type: | Article |
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زبان سند : | انگلیسی |
نویسنده مسئول : | ملیحه نوبخت |
Additional Information: | Indexed In:2- SCOPUS 3-ASCI-Database, EMBASE |
کلیدواژه ها (انگلیسی): | Silibinin , β III tubulin , hair follicle stem cells , nestin , neurotrophion 3 |
Subjects: | QV pharmacology QS Human Anatomy |
Divisions: | Faculty of Medicine > Department of Basic Sciences > Department of Anatomy |
ID Code: | 2051 |
Deposited By: | Dr Nowruz Najafzadeh |
Deposited On: | 26 Nov 1389 08:32 |
Last Modified: | 12 Nov 1391 09:25 |
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