اثرات سیلیبینین روی تمایز سلولهای بنیادی فولیکول مو به سلولهای شبیه نورون

نوبخت, ملیحه and آسالگو, سارا and رهبر روشندل, ناهید and موسوی زاده, کاظم and نجف زاده, نوروز (1389) اثرات سیلیبینین روی تمایز سلولهای بنیادی فولیکول مو به سلولهای شبیه نورون. American Journal of Biochemistry and Molecular Biology ــ 1 (2). pp. 212-222. شاپا 2150-4210

Text - Published Version

Official URL: http://scialert.net/jindex.php?issn=2150-4210


Effects of Silibinin on Hair Follicle Stem Cells Differentiation to Neural-like Cells

English Abstract

Abstract: The hair follicle stem cells are an abundant and easily accessible source of pluripotent adult stem cells. Hairfollicle stem cells differentiate into neurons and glial cells in vitro and express stem cell markers such as tubulin, RIP, P75, and S100. Silibinin, a flavonolignan and the active component of Milk thistle (Silybum Marianum) has been used as a dietary supplement and herbal medication. The aim of the present study was to investigate the effects of Silibinin on hair follicle stem cells differentiation to neural-like cells. The bulge region of the rat whisker was isolated and cultured in Dulbecco’s modified Eagle’s medium supplemented with different concentrations of silibinin and Neurotrophin-3. One week later , bulge cells immunostained with Nestin and p75 and then with tubulin . The morphological and biological features of cultured bulge cells were observed by light microscopy. Present data demonstrated that silibinin (0.5 μg mL-1) can promote differentiation of hair follicle stem cells to neural-like cells.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :ملیحه نوبخت
Additional Information:Indexed In:2- SCOPUS 3-ASCI-Database, EMBASE
کلیدواژه ها (انگلیسی):Silibinin , β III tubulin , hair follicle stem cells , nestin , neurotrophion 3
Subjects:QV pharmacology
QS Human Anatomy
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:2051
Deposited By: Dr Nowruz Najafzadeh
Deposited On:26 Nov 1389 08:32
Last Modified:12 Nov 1391 09:25

Repository Staff Only: item control page

Document Downloads

More statistics for this item...