اثرات methylsulfonylmethane بر colitis تجربی در رت

امیرشاهرخی, کیوان and بهلولی, شهاب and چینی فروش, میرمهدی (1390) اثرات methylsulfonylmethane بر colitis تجربی در رت. Toxicology and Applied Pharmacology ــ 253 (3). pp. 197-202. شاپا 0041-008X

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The effect of methylsulfonylmethane on the experimental colitis in the rat

English Abstract

Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a normal oxidative metabolite of dimethyl sulfoxide. This study was carried out to investigate the effect of MSM in a rat model of experimental colitis. Colitis was induced by intracolonic instillation of 1 ml of 5% of acetic acid. Rats were treated with MSM (400 mg/kg/day, orally) for 4 days. Animals were euthanized and distal colon evaluated histologically and biochemically. Tissue samples were used to measurement of malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), glutathione (GSH) and proinflammatory cytokine (TNF-α and IL-1β) levels. Results showed that MSM decreased macroscopic and microscopic colonic damage scores caused by administration of acetic acid. MSM treatment also significantly reduced colonic levels of MDA, MPO and IL-1β, while increased the levels of GSH and CAT compared with acetic acid-induced colitis group. It seems that MSM as a natural product may have a protective effect in an experimental ulcerative colitis.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :شهاب بهلولی
Additional Information:Impact Factor: 3.359 Abstracting and Indexing : 1- ISI , Science Citation Index Expanded , MEDLINE ,Science Citation Index , 2-BIOSIS , Chemical Abstracts ,Current Contents (Life Sciences,EMBASE ,Scopus 3-Chemical Hazards Index , Clinical Medicine), EMBiology International Pharmaceutical Abstracts , Medical Abstracts Newsletter , Research Alert , Safety Science Abstracts , Toxicology Abstracts
Uncontrolled Keywords:متیل سولفونیل متان ، کولیت تجربی ، التهاب ، متابولیتهای التهاب
کلیدواژه ها (انگلیسی):Methylsulfonylmethane , Experimental colitis , Inflammation , Reactive oxygen metabolites
Subjects:QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pathology
Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:2400
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:09 Mar 1390 12:09
Last Modified:07 Jul 1393 06:08

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