میزان پایین ریشه کنی هلیکوباکتر پیلوری با رژیمهای چهار و هفت روزه در جمعیت ایرانی

ملک زاده, رضا and مرآت, شاهین and درخشان, محمدحسین and سیاوشی, فریده and یزدانبد, عباس and میکاییلی, جواد and ستوده منش, رسول and ستوده, مسعود and فره وش, محمد جعفر and ناصری مقدم, سیاوش and پورشمس, اکرم and دولتشاهی, شهاب and عابدی اردکانی, بهنوش and بابایی, مسعود and عرشی, شهنام and مجیدپور, علی (1382) میزان پایین ریشه کنی هلیکوباکتر پیلوری با رژیمهای چهار و هفت روزه در جمعیت ایرانی. Journal of Gastroenterology and Hepatology ــ 18 (1). pp. 13-17. شاپا 0815-9319

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/jgh.200...


Low Helicobacter pylori eradication rates with 4- and 7-day regimens in an Iranian population

English Abstract

Background: In Iran, there is insufficient information on the efficacy of Helicobacter pylori eradication regimens shorter than 10 days. This study aims at assessing the efficacy of 4- and 7-day H. pylori eradication regimens in a high-incidence area of gastric cancer in Iran. Methods : Subjects with an endoscopic diagnosis of gastritis, positive urease test, and a histological diagnosis of chronic gastritis were enrolled. Patients were randomly assigned to one of three groups: AOC7 (1000mg amoxicillin, 20 mg omeprazole, and 500 mg clarithromycin twice daily for 7 days), FOT4 (200 mg furazolidone, 20 mg omeprazole, and 500 mg tetracycline twice daily for 4 days) and FOT7 (the same treatment as the FOT4 group but for 7 days). Sensitivity to these antibiotics was determined in all isolates recovered from culture. The efficacy of eradication was assessed 8weeks after the end-oftreatment by the 14 C-urea breath test. Results: One hundred and twenty-eight patients were enrolled in the study. Culture was positive for84 patients and none of these were resistant to amoxicillin, tetracycline or furazolidone, 1.2% were resistant to clarithromycin and 32.1% to metronidazole. Forty-five, 41 and 42 patients were randomly allocated to the AOC7, FOT4, and FOT7 groups, respectively. The intention-to-treat eradication rates were 35.5, 17.1, and 23.8% for the AOC7, FOT4, and FOT7 groups, respectively. Conclusion : Treatment regimens of 4 or 7 days are unacceptable for H. pylori infection in Iran, even in the presence of a favorable sensitivity profile.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :رضا ملک زاده
Additional Information:Indexed / Abstracted in: 1- Index Medicus/MEDLINE (NLM) ,Journal Citation Reports/Science Edition (Thomson ISI) , MEDLINE (NLM) ,Science Citation Index (Thomson ISI) Science Citation Index Expanded (also known as SciSearch) 2-SCOPUS (Elsevier) ,EMBASE (Elsevier),BIOSIS Previews (Thomson ISI) 3- Abstracts in Anthropology (Baywood Publishing),Academic Search (EBSCO),Academic Search Premier (EBSCO),AgBiotech News and Information (AgBiotech),BIOBASE: Current Awareness in Biological Sciences (Elsevier) ,Biological Abstracts (Thomson ISI),CAB HEALTH (CABI),CABDirect (CABI),CancerLit (National Cancer Institute/NIH),CAS: Chemical Abstracts Service (CAS),CHID: Combined Health Information Database (NIH),CSA Biological Sciences Database (CSA/CIG) CSA Immunological Abstracts (CSA/CIG),Falk Foundation eV: Hepatology Rapid Literature Review (Falk Foundation eV) HEED: Health Economic Evaluations Database (Wiley-Blackwell) IBIDS: International Bibliographic Information on Dietary Supplements,Index Veterinarius (CABI),LEIsure Tourism Database (LEIsure),LEIsure, Recreation and Tourism Abstracts (LEIsure),National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),ProQuest ,ProtoZoological Abstracts (Elsevier),Research Alert (Thomson ISI),Review of Medical and Veterinary Mycology Soybean Abstracts Online (CABI)
کلیدواژه ها (انگلیسی):Helicobacter pylori ; Iran ; therapeutics
Subjects:WI Digestive System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:2488
Deposited By: Dr Abbas Yazdanbod
Deposited On:27 Apr 1390 09:24
Last Modified:07 Jul 1393 06:53

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