بررسی ارتباط عفونت هلیکوباکتر پیلوری وکانسر حنجره

پیرزاده, اکبر and دوست محمدیان, نجمه and خوشباطن, منوچهر and دوست محمدیان, ثریا (1390) بررسی ارتباط عفونت هلیکوباکتر پیلوری وکانسر حنجره. Asian Pacific journal of cancer prevention : APJCP ــ 12 (4). pp. 897-900. شاپا 1513-7368

Text - Published Version

Official URL: http://www.apocpcontrol.org/page/apjcp_issues.php


Is there any Association between Helicobacter Pylori Infection and Laryngeal Carcinoma

English Abstract

Objective: To investigate the possible role of Helicobacter pylori as a cause of squamous cell carcinoma of larynx in a case-control study in an otolaryngology ward at an academic university. Subjects and Methods: A total of 65 patients with laryngeal cancer and 65 matched cancer-free controls underwent esophagogastroduodenoscopy and biopsy of antral and body regions of the stomach for evaluation of Helicobacter pylori infection. Results:The proportion of subjects with a positive rapid urease test for gastric infection was similar between the two groups (49.2 % in cases vs. 40% in controls). However, a positive rapid urease test for body was less frequently seen in patients with laryngeal cancer whereas a positive rapid urease test for antrum was significantly higher (P=0.04). Conclusion: Our study failed to show Helicobacter pylori as one of the etiologies of laryngeal cancer. However, it supported the hypothesis that colonization of Helicobacter pylori only in the gastric body might have a protective effect against laryngeal cancer with decreasing gastric acid while antral Helicobacter pylori, increasing gastric acid due to G cell hyperplasia, may be a predisposing factor for laryngeal cancer, with acid reflux as a possible underlying etiology. Keywords: Helicobacter pylori - laryngeal cancer - rapid urease test - gastric acid - esophagogastroduodenoscopy

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :اکبر پیرزاده
Additional Information:Impact factor for 2009: 1.240 Indexed on PubMed and Science Citation Index Expanded(ISI
کلیدواژه ها (انگلیسی): urease test - gastric acid - esophagogastroduodenoscopy
Subjects:WV Otolaryngology
Divisions:Faculty of Medicine > Department of Surgery
ID Code:2506
Deposited By: Dr Akbar Pirzadeh
Deposited On:06 Jul 1390 07:44
Last Modified:16 Feb 1393 13:04

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