بررسي سطح پروتيئن كاتيونيك ائوزينوفيل خلط جانبازان شيميائي ريوي و مقايسه آن با گروه كنترل

مير صدرائی, مجيد and قبادی مراللو, حسن and محمدزاده لاری, شهرزاد and خاكزاد, محمد رضا and عطاران, داود and توحیدی, محمد and خواجه دلوئی, محمد and جعفريان, امير حسين (1390) بررسي سطح پروتيئن كاتيونيك ائوزينوفيل خلط جانبازان شيميائي ريوي و مقايسه آن با گروه كنترل. Iranian Journal of Basic Medical Sciences ــ 14 (3). pp. 249-255. شاپا ISSN: 2008-3866

Text - Published Version

Official URL: http://www.mums.ac.ir/basic_medical/en/index


Level of Eosinophil Cationic Protein in Sputum of Chemical Warfare Victims

English Abstract

Objective(s) Considering fair response to inhaled corticosteroids and reports of severe air way hyper responsiveness in chemical warfare victims (CWV), a role for eosinophilic inflammation (i.e. asthma) was postulated. The objective of this study was to determine the presence of eosinophilic inflammation in CWV by evaluation of Sputum cellularity and eosinophil cationic protein (ECP). Materials and Methods Forty CWV and 15 control subjects entered this cross sectional study. Demographic data, dyspnea severity scale, spirometry results and 6 min walk test were determined. Sputum was collected with inducing by nebulizing hypertonic saline and analyzed for total inflammatory cell count, the cellular differential count and ECP level. Control group was normal volunteers with PC20 more than 8 mg/ml. Results Mean±SD of eosinophil percentage (11.7±11.1%) and ECP level in sputum of CWV (46.1±19.5 ng/ml) were significantly more than control group. Regression analysis showed significant correlation between ECP level and percentage of eosinophils in sputum (r= +0.43, P< 0.01). ECP level of CWV subjects with obstructive pattern did not show any significant difference from CWV with normal spirometry. ECP level in CWV subjects who revealed more than 12% improvement in forced expiratory volume in one second (FEV1) was significantly higher than CWV who had improvement less than 12% (P= 0.01). BO and asthma as final clinical diagnosis of CWV did not show any significant difference of sputum ECP. Conclusion Bronchial inflammation in different types of pulmonary complication of CWV is eosinophil dependent. ECP level of sputum in CWV could guide physician to select CWV who would respond to corticosteroids.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مجيد مير صدرائی
نویسنده :حسن قبادی مراللو
نویسنده مسئول :داود عطاران
Additional Information:IF: 0.324 Indexing: International: Science Citation Index Expanded (ISI), Scopus, EMBASE, BIOSIS Previews (Biological Abstracts), Chemical Abstracts (CA), Index Copernicus, Islamic World Science Citation Database (ISC), Index Medicus for the Eastern Mediterranean Region (IMEMR), Google Scholar, Directory of Open Access Journals (DOAJ), CABI, CAB Abstracts database, Global Health database Local: Magiran, Scientific Information Database (SID), Iran Medex
Uncontrolled Keywords:ائوزينوفيل - پروتيئن كاتيونيك ايوزينوفيل - گاز موستارد
کلیدواژه ها (انگلیسی):Chemical warfare agents, Eosinophil, Eosinophil cationic protein, Mustard gas, Sputum
Subjects:WF Respiratory System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:2531
Deposited By: Dr Hassan Ghobadi
Deposited On:15 May 1390 11:06
Last Modified:15 Oct 1398 10:51

Repository Staff Only: item control page

Document Downloads

More statistics for this item...