بررسی موتاسیونهای BRCA1 و BRCA2 در خانواده های ایرانی با خطر بالای سرطان پستان

پیشمن, آندره آ and مهدی پور, پروین and عطری, مرتضی and هوفمن, ورا and حسینی اصل, سید سعید and شرنک, سیگفرید and موندلوس, استفان and پیترز, هارتموت (1383) بررسی موتاسیونهای BRCA1 و BRCA2 در خانواده های ایرانی با خطر بالای سرطان پستان. Journal of Cancer Research and Clinical Oncology ــ 131 (8). pp. 558-552. شاپا 0171-5216

Text - Published Version

Official URL: http://link.springer.com/article/10.1007/s00432-00...


Mutation analysis of BRCA1 and BRCA2 genes in Iranian high risk breast cancer families

English Abstract

Background: Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization. Telomerase has been associated with negative prognostic indicators in some studies. The present study aims to detect any association between telomerase sub-units: hTERT and hTR and the prognostic indicators including tumour's size and grade, nodal status and patient's age. Methods: Tumour samples from 46 patients with primary invasive breast cancer and 3 patients with benign tumours were collected. RT-PCR analysis was used for the detection of hTR, hTERT, and PGM1 (as a housekeeping) genes expression. Results: The expression of hTR and hTERT was found in 31(67.4%) and 38 (82.6%) samples respectively. We observed a significant association between hTR gene expression and younger age at diagnosis (p = 0.019) when comparing patients ≤ 40 years with those who are older than 40 years. None of the benign tumours expressed hTR gene. However, the expression of hTERT gene was revealed in 2 samples. No significant association between hTR and hTERT expression and tumour's grade, stage and nodal status was seen. Conclusion: The expression of hTR and hTERT seems to be independent of tumour's stage. hTR expression probably plays a greater role in mammary tumourogenesis in younger women (≤ 40 years) and this may have therapeutic implications in the context of hTR targeting strategies.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :آندره آ پیشمن
نویسنده مسئول :پروین مهدی پور
نویسنده :مرتضی عطری
نویسنده :ورا هوفمن
نویسنده :سید سعید حسینی اصل
نویسنده :سیگفرید شرنک
نویسنده :استفان موندلوس
نویسنده :هارتموت پیترز
Additional Information:Abstracted/Indexed in: Science Citation Index, Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, CAB International, Academic OneFile, AGRICOLA, Biological Abstracts, BIOSIS, CAB Abstracts, Current Abstracts, Current Contents/ Life Sciences, Elsevier Biobase, Gale, Global Health, Health Reference Center Academic, Index Copernicus, INIS Atomindex, OCLC, PASCAL, SCImago
Uncontrolled Keywords:سرطان پستان ، سرطان تخمدان ، BRCA1, BRCA2, ايران
کلیدواژه ها (انگلیسی):Breast cancer , Ovarian cancer , BRCA1 , BRCA2 , Mutation , Unclassified variants , Iran
Subjects:QY Clinical Pathology
WB Practice of Medicine
WP Gynecology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:2538
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:27 Mar 1392 07:31
Last Modified:10 Jul 1393 08:50

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