بيان ژنهاي hTR و hTERT در سرطان پستان انسان: ارتباط با پارامترهاي آسيب شناسي باليني

حسینی اصل, سید سعید and عطری, مرتضی and مدرسی, محمد حسین and سلحاب, محمد and مکبل, کفاه and مهدی پور, پروین (1384) بيان ژنهاي hTR و hTERT در سرطان پستان انسان: ارتباط با پارامترهاي آسيب شناسي باليني. International Seminars in Surgical Oncology ــ 3 (20). pp. 1-5. شاپا 1477-7800

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Official URL: http://www.issoonline.com/content/3/1/20


The expression of hTR and hTERT in human breast cancer: correlation with clinico-pathological parameters

English Abstract

Background: Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization. Telomerase has been associated with negative prognostic indicators in some studies. The present study aims to detect any association between telomerase sub-units: hTERT and hTR and the prognostic indicators including tumour's size and grade, nodal status and patient's age. Methods: Tumour samples from 46 patients with primary invasive breast cancer and 3 patients with benign tumours were collected. RT-PCR analysis was used for the detection of hTR, hTERT, and PGM1 (as a housekeeping) genes expression. Results: The expression of hTR and hTERT was found in 31(67.4%) and 38 (82.6%) samples respectively. We observed a significant association between hTR gene expression and younger age at diagnosis (p = 0.019) when comparing patients ≤ 40 years with those who are older than 40 years. None of the benign tumours expressed hTR gene. However, the expression of hTERT gene was revealed in 2 samples. No significant association between hTR and hTERT expression and tumour's grade, stage and nodal status was seen. Conclusion: The expression of hTR and hTERT seems to be independent of tumour's stage. hTR expression probably plays a greater role in mammary tumourogenesis in younger women (≤ 40 years) and this may have therapeutic implications in the context of hTR targeting strategies.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سید سعید حسینی اصل
نویسنده :مرتضی عطری
نویسنده :محمد حسین مدرسی
نویسنده :محمد سلحاب
نویسنده :کفاه مکبل
نویسنده مسئول :پروین مهدی پور
Uncontrolled Keywords:سرطان پستان، hTR، hTERT
کلیدواژه ها (انگلیسی):Breast cancer , hTERT , hTR
Subjects:QY Clinical Pathology
WB Practice of Medicine
WP Gynecology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:2540
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:27 Mar 1392 07:44
Last Modified:10 Jul 1393 08:37

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