مطالعه غلظت سرمی MMP-9 در افراد مبتلا به هلیکوباکتر پیلوری

اتحاد, غلامحسین and امانی, مجتبی and پرستار, ندا (1390) مطالعه غلظت سرمی MMP-9 در افراد مبتلا به هلیکوباکتر پیلوری. در: پنجمین کنفرانس بین المللی بیماریهای عفونی, 14-17 جولای 2011, پکن-چین.

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Investigation on MMP-9 concentration in sera of people infected by Helicobacter pylori

English Abstract

Objectives: Helicobacter Pylori (HP), as a gram negative bacterium colonizing in the gastric mucosa, induces gastrodeudenal complications varying from mild gastritis to gastric malignancies. mmp-9, an enzyme with protease activity, plays key role in cancer induction and metathesis. Regarding to high incidence of gastric cancer in Ardabil province, the present study was conducted with the following major question whether the increase of serum level of mmp-9 can be seen before induction of cancer by H.P. Methods: Serum and stool specimens together were obtained from 200 apparently healthy individuals. Samples were stored at 70�C until ELISA experiments. ELISA kits were used to assess H. Pylori Ag in stools and serum concentration of mmp-9. Results: Obtained results showed increase of serum level of mmp-9 in H.P infected person in comparison to healthy ones. Discussion: Albeit our results show increase in serum level of mmp-9 in infected persons but this is not significant. Previous studies showed significant increase in mmp-9 concentration in biopsy samples prepared from H.P. infected persons. This controversy may arise from differences in studied population, variety of H.P., the manner of sampling and detection of H.P. infection. We suggest making a similar investigation with special regards to these factors.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :غلامحسین اتحاد
Uncontrolled Keywords:سرطان معده ، هلیکوباکتر پیلوری ، متالوپروتئیناز-9
کلیدواژه ها (انگلیسی):MMp-9, Gatric cancer, H. pylori
Subjects:QU Biochemistry
QW Microbiology and Immunology
WI Digestive System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biophysics
Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:2569
Deposited By: Dr Mojtaba Amani
Deposited On:20 May 1390 10:39
Last Modified:21 Jan 1393 09:27

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